Frequently Asked
Common questions about Piperidine-4-carbonitrile
What is Piperidine-4-carbonitrile used for?
Piperidine-4-carbonitrile is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles used primarily in the pharmaceutical and cns therapeutics industries. Key applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and hydrolysis to carboxylic acids or amides under controlled conditions.
Where can I buy Piperidine-4-carbonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of Piperidine-4-carbonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Piperidine-4-carbonitrile?
ChemContract Research supplies Piperidine-4-carbonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Piperidine-4-carbonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Piperidine-4-carbonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What drug discovery applications use Piperidine-4-carbonitrile?
The Piperidine ring system(s) in Piperidine-4-carbonitrile is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Can the nitrile group in Piperidine-4-carbonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in Piperidine-4-carbonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
How should I store Piperidine-4-carbonitrile?
Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Piperidine-4-carbonitrile?
The CAS Registry Number for Piperidine-4-carbonitrile is 4395-98-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
