CAS 4553-21-3 · Amine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days
1-(2-Aminoethyl)-4-benzylpiperazine (CAS Number: 4553-21-3) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Piperazine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. The two nitrogen atoms of piperazine provide both a basic amine (pKa ~9.8) for salt formation and a secondary amine (pKa ~5.3) for functionalization, giving medicinal chemists dual synthetic handles.
Primary applications include buchwald–hartwig amination for aryl c–n bond construction and solubility enhancer via piperazine salt formation in drug formulation. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require 1-(2-Aminoethyl)-4-benzylpiperazine for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 1-(2-Aminoethyl)-4-benzylpiperazine is used across pharmaceutical and polymer sectors
Buchwald–Hartwig amination for aryl C–N bond construction
Solubility enhancer via piperazine salt formation in drug formulation
Reductive amination with aldehydes and ketones for secondary amine synthesis
Bioisosteric replacement for piperidine to improve metabolic profile
Salt formation to improve drug solubility and bioavailability
Antipsychotic and anxiolytic drug scaffold (aripiprazole class)
Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with standard precautions. Some piperazine derivatives may be irritating. Use adequate ventilation.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container away from acids.
Amines are the most prevalent pharmacophore in drug molecules. 1-(2-Aminoethyl)-4-benzylpiperazine is supplied with salt-form options and free-base conversion protocols.
Every batch of 1-(2-Aminoethyl)-4-benzylpiperazine is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 1-(2-Aminoethyl)-4-benzylpiperazine? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 1-(2-Aminoethyl)-4-benzylpiperazine
1-(2-Aminoethyl)-4-benzylpiperazine is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and solubility enhancer via piperazine salt formation in drug formulation.
ChemContract Research is a trusted USA-based supplier of 1-(2-Aminoethyl)-4-benzylpiperazine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 1-(2-Aminoethyl)-4-benzylpiperazine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 1-(2-Aminoethyl)-4-benzylpiperazine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The amine functionality in 1-(2-Aminoethyl)-4-benzylpiperazine enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
The Piperazine ring system(s) in 1-(2-Aminoethyl)-4-benzylpiperazine is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container away from acids. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 1-(2-Aminoethyl)-4-benzylpiperazine is 4553-21-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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