Frequently Asked
Common questions about N-Boc-N,N-bis(2-chloroethyl)amine
What is N-Boc-N,N-bis(2-chloroethyl)amine used for?
N-Boc-N,N-bis(2-chloroethyl)amine is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and nucleophilic aromatic substitution (snar) for ether and amine formation.
Where can I buy N-Boc-N,N-bis(2-chloroethyl)amine in the USA?
ChemContract Research is a trusted USA-based supplier of N-Boc-N,N-bis(2-chloroethyl)amine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for N-Boc-N,N-bis(2-chloroethyl)amine?
ChemContract Research supplies N-Boc-N,N-bis(2-chloroethyl)amine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize N-Boc-N,N-bis(2-chloroethyl)amine in custom quantities?
Yes. ChemContract Research offers custom synthesis services for N-Boc-N,N-bis(2-chloroethyl)amine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What reactions can I perform with the amine group in N-Boc-N,N-bis(2-chloroethyl)amine?
The amine functionality in N-Boc-N,N-bis(2-chloroethyl)amine enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How do I remove the Boc group from N-Boc-N,N-bis(2-chloroethyl)amine?
The Boc protecting group in N-Boc-N,N-bis(2-chloroethyl)amine is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store N-Boc-N,N-bis(2-chloroethyl)amine?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of N-Boc-N,N-bis(2-chloroethyl)amine?
The CAS Registry Number for N-Boc-N,N-bis(2-chloroethyl)amine is 118753-70-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
