Frequently Asked
Common questions about 1-(2-Boc-aminoethyl)piperazine
What is 1-(2-Boc-aminoethyl)piperazine used for?
1-(2-Boc-aminoethyl)piperazine is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and solubility enhancer via piperazine salt formation in drug formulation.
Where can I buy 1-(2-Boc-aminoethyl)piperazine in the USA?
ChemContract Research is a trusted USA-based supplier of 1-(2-Boc-aminoethyl)piperazine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 1-(2-Boc-aminoethyl)piperazine?
ChemContract Research supplies 1-(2-Boc-aminoethyl)piperazine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 1-(2-Boc-aminoethyl)piperazine in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 1-(2-Boc-aminoethyl)piperazine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What reactions can I perform with the amine group in 1-(2-Boc-aminoethyl)piperazine?
The amine functionality in 1-(2-Boc-aminoethyl)piperazine enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How do I remove the Boc group from 1-(2-Boc-aminoethyl)piperazine?
The Boc protecting group in 1-(2-Boc-aminoethyl)piperazine is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store 1-(2-Boc-aminoethyl)piperazine?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 1-(2-Boc-aminoethyl)piperazine?
The CAS Registry Number for 1-(2-Boc-aminoethyl)piperazine is 140447-78-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
