Frequently Asked
Common questions about Boc-Val-chloromethylketone
What is Boc-Val-chloromethylketone used for?
Boc-Val-chloromethylketone is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy Boc-Val-chloromethylketone in the USA?
ChemContract Research is a trusted USA-based supplier of Boc-Val-chloromethylketone. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Boc-Val-chloromethylketone?
ChemContract Research supplies Boc-Val-chloromethylketone in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Boc-Val-chloromethylketone in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Boc-Val-chloromethylketone from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
How do I remove the Boc group from Boc-Val-chloromethylketone?
The Boc protecting group in Boc-Val-chloromethylketone is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
What coupling reactions can I run with Boc-Val-chloromethylketone?
As a chlorinated compound, Boc-Val-chloromethylketone is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store Boc-Val-chloromethylketone?
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Boc-Val-chloromethylketone?
The CAS Registry Number for Boc-Val-chloromethylketone is 103542-47-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
