Frequently Asked
Common questions about Boc-D-Phe chloromethyl ketone
What is Boc-D-Phe chloromethyl ketone used for?
Boc-D-Phe chloromethyl ketone is a ketone-containing compound with a carbonyl center flanked by carbon substituents used primarily in the pharmaceutical and fine chemical industries. Key applications include asymmetric reduction to chiral alcohols using cbs or noyori catalysts and nucleophilic aromatic substitution (snar) for ether and amine formation.
Where can I buy Boc-D-Phe chloromethyl ketone in the USA?
ChemContract Research is a trusted USA-based supplier of Boc-D-Phe chloromethyl ketone. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Boc-D-Phe chloromethyl ketone?
ChemContract Research supplies Boc-D-Phe chloromethyl ketone in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Boc-D-Phe chloromethyl ketone in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Boc-D-Phe chloromethyl ketone from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
How do I remove the Boc group from Boc-D-Phe chloromethyl ketone?
The Boc protecting group in Boc-D-Phe chloromethyl ketone is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
What coupling reactions can I run with Boc-D-Phe chloromethyl ketone?
As a chlorinated compound, Boc-D-Phe chloromethyl ketone is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store Boc-D-Phe chloromethyl ketone?
Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Boc-D-Phe chloromethyl ketone?
The CAS Registry Number for Boc-D-Phe chloromethyl ketone is 150935-37-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
