Frequently Asked
Common questions about 4-(difluoromethyl)piperidine
What is 4-(difluoromethyl)piperidine used for?
4-(difluoromethyl)piperidine is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and cns drug scaffold (present in donepezil, methylphenidate, fentanyl class).
Where can I buy 4-(difluoromethyl)piperidine in the USA?
ChemContract Research is a trusted USA-based supplier of 4-(difluoromethyl)piperidine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 4-(difluoromethyl)piperidine?
ChemContract Research supplies 4-(difluoromethyl)piperidine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 4-(difluoromethyl)piperidine in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 4-(difluoromethyl)piperidine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What drug discovery applications use 4-(difluoromethyl)piperidine?
The Piperidine ring system(s) in 4-(difluoromethyl)piperidine is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Why is fluorine important in 4-(difluoromethyl)piperidine?
The fluorine atom(s) in 4-(difluoromethyl)piperidine confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 4-(difluoromethyl)piperidine valuable in pharmaceutical development.
How should I store 4-(difluoromethyl)piperidine?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 4-(difluoromethyl)piperidine?
The CAS Registry Number for 4-(difluoromethyl)piperidine is 1283717-58-7. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
