Frequently Asked
Common questions about 2-(4-Boc-piperazin-1-yl)benzoic acid
What is 2-(4-Boc-piperazin-1-yl)benzoic acid used for?
2-(4-Boc-piperazin-1-yl)benzoic acid is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy 2-(4-Boc-piperazin-1-yl)benzoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of 2-(4-Boc-piperazin-1-yl)benzoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 2-(4-Boc-piperazin-1-yl)benzoic acid?
ChemContract Research supplies 2-(4-Boc-piperazin-1-yl)benzoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 2-(4-Boc-piperazin-1-yl)benzoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 2-(4-Boc-piperazin-1-yl)benzoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What drug discovery applications use 2-(4-Boc-piperazin-1-yl)benzoic acid?
The Piperazine ring system(s) in 2-(4-Boc-piperazin-1-yl)benzoic acid is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
How do I remove the Boc group from 2-(4-Boc-piperazin-1-yl)benzoic acid?
The Boc protecting group in 2-(4-Boc-piperazin-1-yl)benzoic acid is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store 2-(4-Boc-piperazin-1-yl)benzoic acid?
Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 2-(4-Boc-piperazin-1-yl)benzoic acid?
The CAS Registry Number for 2-(4-Boc-piperazin-1-yl)benzoic acid is 444582-90-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
