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2-(4-Boc-piperazin-1-yl-methyl)aniline

CAS 885278-02-4 · Piperazine · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Piperazine

2-(4-Boc-piperazin-1-yl-methyl)aniline

Boc-Protected PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryPeptide SynthesisFine Chemical
CAS Number 885278-02-4
Category Piperazine · Boc-Protected
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 2-(4-Boc-piperazin-1-yl-methyl)aniline

2-(4-Boc-piperazin-1-yl-methyl)aniline (CAS Number: 885278-02-4) is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif featuring a Piperazine ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The two nitrogen atoms of piperazine provide both a basic amine (pKa ~9.8) for salt formation and a secondary amine (pKa ~5.3) for functionalization, giving medicinal chemists dual synthetic handles. The Boc group is removed cleanly with TFA or HCl in dioxane, making it orthogonal to Fmoc, Cbz, and Alloc protecting groups — essential for synthesizing complex peptide therapeutics. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.

Primary applications include solubility enhancer via piperazine salt formation in drug formulation and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require 2-(4-Boc-piperazin-1-yl-methyl)aniline for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Piperazine
Functional Groups: Boc protecting group
Stereochemistry: Defined Configuration

Piperazine Applications & Target Industries

How 2-(4-Boc-piperazin-1-yl-methyl)aniline is used across pharmaceutical and cns therapeutics sectors

01

Solubility enhancer via piperazine salt formation in drug formulation

02

Solid-phase peptide synthesis (SPPS) with orthogonal Boc/Fmoc strategies

03

Enantiopure building block for single-enantiomer drug development

04

Bioisosteric replacement for piperidine to improve metabolic profile

05

Multi-step pharmaceutical synthesis requiring selective amine deprotection

06

Chiral resolution standard or chiral HPLC reference compound

Target Industries: PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryPeptide SynthesisFine Chemical

2-(4-Boc-piperazin-1-yl-methyl)aniline Specifications

Detailed specifications for this piperazine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 2-(4-Boc-piperazin-1-yl-methyl)aniline
Type Piperazine
Category Piperazine · Boc-Protected
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Piperazines

Handling Guidelines

Handle with standard precautions. Some piperazine derivatives may be irritating. Use adequate ventilation. Boc-protected compounds are generally stable. TFA deprotection generates isobutylene gas — perform in a fume hood. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 2-(4-Boc-piperazin-1-yl-methyl)aniline From ChemContract?

Quality Assured

Every batch of 2-(4-Boc-piperazin-1-yl-methyl)aniline is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 2-(4-Boc-piperazin-1-yl-methyl)aniline? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 2-(4-Boc-piperazin-1-yl-methyl)aniline

What is 2-(4-Boc-piperazin-1-yl-methyl)aniline used for? +

2-(4-Boc-piperazin-1-yl-methyl)aniline is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.

Where can I buy 2-(4-Boc-piperazin-1-yl-methyl)aniline in the USA? +

ChemContract Research is a trusted USA-based supplier of 2-(4-Boc-piperazin-1-yl-methyl)aniline. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 2-(4-Boc-piperazin-1-yl-methyl)aniline? +

ChemContract Research supplies 2-(4-Boc-piperazin-1-yl-methyl)aniline in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 2-(4-Boc-piperazin-1-yl-methyl)aniline in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 2-(4-Boc-piperazin-1-yl-methyl)aniline from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What is the stereochemical purity of 2-(4-Boc-piperazin-1-yl-methyl)aniline? +

ChemContract Research supplies 2-(4-Boc-piperazin-1-yl-methyl)aniline with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

What drug discovery applications use 2-(4-Boc-piperazin-1-yl-methyl)aniline? +

The Piperazine ring system(s) in 2-(4-Boc-piperazin-1-yl-methyl)aniline is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store 2-(4-Boc-piperazin-1-yl-methyl)aniline? +

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 2-(4-Boc-piperazin-1-yl-methyl)aniline? +

The CAS Registry Number for 2-(4-Boc-piperazin-1-yl-methyl)aniline is 885278-02-4. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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