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1-(tert-Butyl)piperazine dihydrochloride

CAS 110469-59-5 · Piperazine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Piperazine

1-(tert-Butyl)piperazine dihydrochloride

Piperidines PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryFormulationAnalytical Chemistry
CAS Number 110469-59-5
Category Piperazine · Hydrochloride Salt
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 1-(tert-Butyl)piperazine dihydrochloride

1-(tert-Butyl)piperazine dihydrochloride (CAS Number: 110469-59-5) is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif featuring a Piperazine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The two nitrogen atoms of piperazine provide both a basic amine (pKa ~9.8) for salt formation and a secondary amine (pKa ~5.3) for functionalization, giving medicinal chemists dual synthetic handles. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include solubility enhancer via piperazine salt formation in drug formulation and improved handling characteristics versus the free base form. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require 1-(tert-Butyl)piperazine dihydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Piperazine
Functional Groups: Chlorine (C–Cl)
Salt Form: Hydrochloride

Piperazine Applications & Target Industries

How 1-(tert-Butyl)piperazine dihydrochloride is used across pharmaceutical and cns therapeutics sectors

01

Solubility enhancer via piperazine salt formation in drug formulation

02

Improved handling characteristics versus the free base form

03

Bioisosteric replacement for piperidine to improve metabolic profile

04

Direct formulation excipient in oral solid dosage forms

05

Antipsychotic and anxiolytic drug scaffold (aripiprazole class)

06

Crystalline form screening for polymorph and salt studies

Target Industries: PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryFormulationAnalytical Chemistry

1-(tert-Butyl)piperazine dihydrochloride Specifications

Detailed specifications for this piperazine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 1-(tert-Butyl)piperazine dihydrochloride
Type Piperazine
Category Piperazine · Hydrochloride Salt
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Simple (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Piperazines

Handling Guidelines

Handle with standard precautions. Some piperazine derivatives may be irritating. Use adequate ventilation. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy 1-(tert-Butyl)piperazine dihydrochloride From ChemContract?

Quality Assured

Every batch of 1-(tert-Butyl)piperazine dihydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 1-(tert-Butyl)piperazine dihydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 1-(tert-Butyl)piperazine dihydrochloride

What is 1-(tert-Butyl)piperazine dihydrochloride used for? +

1-(tert-Butyl)piperazine dihydrochloride is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and improved handling characteristics versus the free base form.

Where can I buy 1-(tert-Butyl)piperazine dihydrochloride in the USA? +

ChemContract Research is a trusted USA-based supplier of 1-(tert-Butyl)piperazine dihydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 1-(tert-Butyl)piperazine dihydrochloride? +

ChemContract Research supplies 1-(tert-Butyl)piperazine dihydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 1-(tert-Butyl)piperazine dihydrochloride in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 1-(tert-Butyl)piperazine dihydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get 1-(tert-Butyl)piperazine dihydrochloride in a different salt form or as the free base? +

Yes. ChemContract Research can supply 1-(tert-Butyl)piperazine dihydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What drug discovery applications use 1-(tert-Butyl)piperazine dihydrochloride? +

The Piperazine ring system(s) in 1-(tert-Butyl)piperazine dihydrochloride is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store 1-(tert-Butyl)piperazine dihydrochloride? +

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 1-(tert-Butyl)piperazine dihydrochloride? +

The CAS Registry Number for 1-(tert-Butyl)piperazine dihydrochloride is 110469-59-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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