CAS 110469-59-5 · Piperazine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days
1-(tert-Butyl)piperazine dihydrochloride (CAS Number: 110469-59-5) is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif featuring a Piperazine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.
The two nitrogen atoms of piperazine provide both a basic amine (pKa ~9.8) for salt formation and a secondary amine (pKa ~5.3) for functionalization, giving medicinal chemists dual synthetic handles. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.
Primary applications include solubility enhancer via piperazine salt formation in drug formulation and improved handling characteristics versus the free base form. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require 1-(tert-Butyl)piperazine dihydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 1-(tert-Butyl)piperazine dihydrochloride is used across pharmaceutical and cns therapeutics sectors
Solubility enhancer via piperazine salt formation in drug formulation
Improved handling characteristics versus the free base form
Bioisosteric replacement for piperidine to improve metabolic profile
Direct formulation excipient in oral solid dosage forms
Antipsychotic and anxiolytic drug scaffold (aripiprazole class)
Crystalline form screening for polymorph and salt studies
Detailed specifications for this piperazine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Handle with standard precautions. Some piperazine derivatives may be irritating. Use adequate ventilation. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.
Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container. Protect from humidity.
Piperazine motifs improve drug solubility. 1-(tert-Butyl)piperazine dihydrochloride is available with salt-form screening data to accelerate your formulation development.
Every batch of 1-(tert-Butyl)piperazine dihydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 1-(tert-Butyl)piperazine dihydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 1-(tert-Butyl)piperazine dihydrochloride
1-(tert-Butyl)piperazine dihydrochloride is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and improved handling characteristics versus the free base form.
ChemContract Research is a trusted USA-based supplier of 1-(tert-Butyl)piperazine dihydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 1-(tert-Butyl)piperazine dihydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 1-(tert-Butyl)piperazine dihydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Yes. ChemContract Research can supply 1-(tert-Butyl)piperazine dihydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.
The Piperazine ring system(s) in 1-(tert-Butyl)piperazine dihydrochloride is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 1-(tert-Butyl)piperazine dihydrochloride is 110469-59-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
Get competitive pricing, custom quantities, and fast USA delivery. Our chemistry team is standing by to provide specifications, CoA documentation, and a tailored quote for your project.
Or call us directly: +1 (714) 732-8549
Hi there! How can we help you today?