Frequently Asked
Common questions about N-Boc-4-hydroxy piperidine
What is N-Boc-4-hydroxy piperidine used for?
N-Boc-4-hydroxy piperidine is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles used primarily in the pharmaceutical and cns therapeutics industries. Key applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy N-Boc-4-hydroxy piperidine in the USA?
ChemContract Research is a trusted USA-based supplier of N-Boc-4-hydroxy piperidine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for N-Boc-4-hydroxy piperidine?
ChemContract Research supplies N-Boc-4-hydroxy piperidine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize N-Boc-4-hydroxy piperidine in custom quantities?
Yes. ChemContract Research offers custom synthesis services for N-Boc-4-hydroxy piperidine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What drug discovery applications use N-Boc-4-hydroxy piperidine?
The Piperidine ring system(s) in N-Boc-4-hydroxy piperidine is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
How do I remove the Boc group from N-Boc-4-hydroxy piperidine?
The Boc protecting group in N-Boc-4-hydroxy piperidine is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store N-Boc-4-hydroxy piperidine?
Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of N-Boc-4-hydroxy piperidine?
The CAS Registry Number for N-Boc-4-hydroxy piperidine is 109384-19-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
