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N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide

CAS 1372407-07-2 · Amine · 6 functional traits · cGMP compliant · Ships from USA in 2-3 days

Amine

N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide

Fluorinated PharmaceuticalPolymerAgrochemicalCatalysisFine ChemicalResearch
CAS Number 1372407-07-2
Category Amine · Ketone
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
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About N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide

N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide (CAS Number: 1372407-07-2) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring Pyridine, Pyrimidine, Pyrrole ring systems with defined stereochemistry. ChemContract Research supplies this complex-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. Ketones serve as strategic intermediates in retrosynthetic planning — their carbonyl can be disconnected in multiple directions, providing flexible synthetic access to complex targets. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates.

Primary applications include buchwald–hartwig amination for aryl c–n bond construction and asymmetric reduction to chiral alcohols using cbs or noyori catalysts. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: PyridinePyrimidinePyrrolePyrrolidineCyclohexane
Functional Groups: Amine (–NH₂/–NHR)Amide (–CONH–)Hydroxyl (–OH)Fluorine (C–F)
Stereochemistry: Defined Configuration

Amine Applications & Target Industries

How N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide is used across pharmaceutical and polymer sectors

01

Buchwald–Hartwig amination for aryl C–N bond construction

02

Asymmetric reduction to chiral alcohols using CBS or Noyori catalysts

03

Metabolic blocking strategy — fluorine substitution to improve drug half-life

04

Mitsunobu reaction substrate for stereospecific inversion at chiral centers

05

Peptide bond mimetic for peptidomimetic drug design

06

Enantiopure building block for single-enantiomer drug development

Target Industries: PharmaceuticalPolymerAgrochemicalCatalysisFine ChemicalResearch

N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide Specifications

Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide
Type Amine
Category Amine · Ketone
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Complex (4 functional groups, 5 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Amines

Handling Guidelines

Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with standard laboratory precautions. Some ketones are flammable. Use adequate ventilation and wear safety glasses and gloves. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Handle with standard precautions. Some alcohols are flammable. Use adequate ventilation and appropriate PPE. Handle with standard laboratory precautions. Consult the SDS for compound-specific hazards. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide From ChemContract?

Quality Assured

Every batch of N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide

What is N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide used for? +

N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and asymmetric reduction to chiral alcohols using cbs or noyori catalysts.

Where can I buy N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide in the USA? +

ChemContract Research is a trusted USA-based supplier of N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? +

ChemContract Research supplies N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Why is fluorine important in N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? +

The fluorine atom(s) in N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide valuable in pharmaceutical development.

What is the stereochemical purity of N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? +

ChemContract Research supplies N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? +

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide? +

The CAS Registry Number for N-{2-oxo-2-[(3S)-3-{[cis-4-hydroxy-4-[5-(pyrimidin-2-yl)pyridin-2-yl]cyclohexyl]amino}pyrrolidin-1-yl]ethyl}-3-(trifluoromethyl)benzamide is 1372407-07-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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