Frequently Asked
Common questions about N-1-Boc-2-piperazinecarboxylic acid methyl ester
What is N-1-Boc-2-piperazinecarboxylic acid methyl ester used for?
N-1-Boc-2-piperazinecarboxylic acid methyl ester is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and solid-phase peptide synthesis (spps) with orthogonal boc/fmoc strategies.
Where can I buy N-1-Boc-2-piperazinecarboxylic acid methyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of N-1-Boc-2-piperazinecarboxylic acid methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for N-1-Boc-2-piperazinecarboxylic acid methyl ester?
ChemContract Research supplies N-1-Boc-2-piperazinecarboxylic acid methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize N-1-Boc-2-piperazinecarboxylic acid methyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for N-1-Boc-2-piperazinecarboxylic acid methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What drug discovery applications use N-1-Boc-2-piperazinecarboxylic acid methyl ester?
The Piperazine ring system(s) in N-1-Boc-2-piperazinecarboxylic acid methyl ester is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
How do I remove the Boc group from N-1-Boc-2-piperazinecarboxylic acid methyl ester?
The Boc protecting group in N-1-Boc-2-piperazinecarboxylic acid methyl ester is cleanly removed by treatment with trifluoroacetic acid (TFA, 20–50% in DCM) at room temperature, typically within 30–60 minutes. Alternative conditions include HCl in dioxane (4M) or trimethylsilyl triflate with 2,6-lutidine. The Boc group is stable to base, hydrogenation, and many nucleophilic conditions, making it orthogonal to Fmoc and Cbz groups.
How should I store N-1-Boc-2-piperazinecarboxylic acid methyl ester?
Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a sealed container. Stable under neutral and basic conditions; avoid strong acids during storage. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of N-1-Boc-2-piperazinecarboxylic acid methyl ester?
The CAS Registry Number for N-1-Boc-2-piperazinecarboxylic acid methyl ester is 129799-15-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
