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Methyl4-chloro-2-nitrobenzoate

CAS 42087-80-9 · Chlorinated Compound · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Chlorinated Compound

Methyl4-chloro-2-nitrobenzoate

Halogenated PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingPolymerGreen Chemistry
CAS Number 42087-80-9
Category Chlorinated Compound · Ester
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About Methyl4-chloro-2-nitrobenzoate

Methyl4-chloro-2-nitrobenzoate (CAS Number: 42087-80-9) is a chloro-substituted intermediate widely used in nucleophilic displacement reactions. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.

Primary applications include nucleophilic aromatic substitution (snar) for ether and amine formation and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require Methyl4-chloro-2-nitrobenzoate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Functional Groups: Ester (–COOR)Chlorine (C–Cl)

Chlorinated Compound Applications & Target Industries

How Methyl4-chloro-2-nitrobenzoate is used across pharmaceutical and agrochemical sectors

01

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

02

Prodrug development to mask carboxylic acids and improve membrane permeability

03

Grignard reagent precursor for C–C bond construction

04

Protecting group for hydroxyl functionalities (acetate, benzoate)

05

Acyl chloride reactivity for amide and ester formation

06

Ring-opening polymerization monomer for biodegradable polymers

Target Industries: PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingPolymerGreen Chemistry

Methyl4-chloro-2-nitrobenzoate Specifications

Detailed specifications for this chlorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name Methyl4-chloro-2-nitrobenzoate
Type Chlorinated Compound
Category Chlorinated Compound · Ester
Purity ≥95% (custom grades available)
Complexity Simple (2 functional groups, 0 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Chlorinated Compounds

Handling Guidelines

Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.

Storage Conditions

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame.

Why Buy Methyl4-chloro-2-nitrobenzoate From ChemContract?

Quality Assured

Every batch of Methyl4-chloro-2-nitrobenzoate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of Methyl4-chloro-2-nitrobenzoate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about Methyl4-chloro-2-nitrobenzoate

What is Methyl4-chloro-2-nitrobenzoate used for? +

Methyl4-chloro-2-nitrobenzoate is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and prodrug development to mask carboxylic acids and improve membrane permeability.

Where can I buy Methyl4-chloro-2-nitrobenzoate in the USA? +

ChemContract Research is a trusted USA-based supplier of Methyl4-chloro-2-nitrobenzoate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for Methyl4-chloro-2-nitrobenzoate? +

ChemContract Research supplies Methyl4-chloro-2-nitrobenzoate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize Methyl4-chloro-2-nitrobenzoate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for Methyl4-chloro-2-nitrobenzoate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What coupling reactions can I run with Methyl4-chloro-2-nitrobenzoate? +

As a chlorinated compound, Methyl4-chloro-2-nitrobenzoate is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store Methyl4-chloro-2-nitrobenzoate? +

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of Methyl4-chloro-2-nitrobenzoate? +

The CAS Registry Number for Methyl4-chloro-2-nitrobenzoate is 42087-80-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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