CAS 680-15-9 · Sulfur-Containing Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
Methyl fluorosulfonyldifluoroacetate (CAS Number: 680-15-9) is a sulfur-functionalized compound with diverse reactivity. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.
Primary applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require Methyl fluorosulfonyldifluoroacetate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How Methyl fluorosulfonyldifluoroacetate is used across pharmaceutical and medicinal chemistry sectors
Sulfonamide pharmacophore installation for antibiotic and diuretic development
Metabolic blocking strategy — fluorine substitution to improve drug half-life
Prodrug development to mask carboxylic acids and improve membrane permeability
Tosyl and mesyl protecting groups for hydroxyl and amine functionalities
PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging
Protecting group for hydroxyl functionalities (acetate, benzoate)
Detailed specifications for this sulfur-containing compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame.
Every batch of Methyl fluorosulfonyldifluoroacetate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of Methyl fluorosulfonyldifluoroacetate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about Methyl fluorosulfonyldifluoroacetate
Methyl fluorosulfonyldifluoroacetate is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and metabolic blocking strategy — fluorine substitution to improve drug half-life.
ChemContract Research is a trusted USA-based supplier of Methyl fluorosulfonyldifluoroacetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies Methyl fluorosulfonyldifluoroacetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for Methyl fluorosulfonyldifluoroacetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The fluorine atom(s) in Methyl fluorosulfonyldifluoroacetate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like Methyl fluorosulfonyldifluoroacetate valuable in pharmaceutical development.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for Methyl fluorosulfonyldifluoroacetate is 680-15-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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