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methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid

CAS 1807558-16-2 · Amine · 5 functional traits · cGMP compliant · Ships from USA in 2-3 days

Amine

methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid

Fluorinated PharmaceuticalPolymerAgrochemicalCatalysisDiagnostic ImagingMaterials Science
CAS Number 1807558-16-2
Category Amine · Fluorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid

methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid (CAS Number: 1807558-16-2) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Cyclobutane ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the trifluoroacetate salt form for enhanced stability and handling.

Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step.

Primary applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Cyclobutane
Functional Groups: Amine (–NH₂/–NHR)Carboxylic acid (–COOH)Fluorine (C–F)
Stereochemistry: Defined Configuration
Salt Form: Trifluoroacetate

Amine Applications & Target Industries

How methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is used across pharmaceutical and polymer sectors

01

Buchwald–Hartwig amination for aryl C–N bond construction

02

Metabolic blocking strategy — fluorine substitution to improve drug half-life

03

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

04

Commonly isolated form from Boc deprotection in peptide synthesis

05

Enantiopure building block for single-enantiomer drug development

06

Reductive amination with aldehydes and ketones for secondary amine synthesis

Target Industries: PharmaceuticalPolymerAgrochemicalCatalysisDiagnostic ImagingMaterials Science

methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid Specifications

Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid
Type Amine
Category Amine · Fluorinated Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Salt Form Trifluoroacetate
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Amines

Handling Guidelines

Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. TFA salts are hygroscopic. Handle in a dry environment. TFA is corrosive — wear chemical-resistant gloves. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid From ChemContract?

Quality Assured

Every batch of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid

What is methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid used for? +

methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.

Where can I buy methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid in the USA? +

ChemContract Research is a trusted USA-based supplier of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? +

ChemContract Research supplies methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Why is fluorine important in methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? +

The fluorine atom(s) in methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid valuable in pharmaceutical development.

What is the stereochemical purity of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? +

ChemContract Research supplies methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? +

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? +

The CAS Registry Number for methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is 1807558-16-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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