CAS 1807558-16-2 · Amine · 5 functional traits · cGMP compliant · Ships from USA in 2-3 days
methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid (CAS Number: 1807558-16-2) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Cyclobutane ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the trifluoroacetate salt form for enhanced stability and handling.
Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step.
Primary applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is used across pharmaceutical and polymer sectors
Buchwald–Hartwig amination for aryl C–N bond construction
Metabolic blocking strategy — fluorine substitution to improve drug half-life
Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis
Commonly isolated form from Boc deprotection in peptide synthesis
Enantiopure building block for single-enantiomer drug development
Reductive amination with aldehydes and ketones for secondary amine synthesis
Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. TFA salts are hygroscopic. Handle in a dry environment. TFA is corrosive — wear chemical-resistant gloves. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.
Amines are the most prevalent pharmacophore in drug molecules. methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is supplied with salt-form options and free-base conversion protocols.
Every batch of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid
methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.
ChemContract Research is a trusted USA-based supplier of methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The fluorine atom(s) in methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid valuable in pharmaceutical development.
ChemContract Research supplies methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for methyl cis-2-aminocyclobutane-1-carboxylate; trifluoroacetic acid is 1807558-16-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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