Frequently Asked
Common questions about Methyl 3-cyano-4-fluorobenzoate
What is Methyl 3-cyano-4-fluorobenzoate used for?
Methyl 3-cyano-4-fluorobenzoate is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability.
Where can I buy Methyl 3-cyano-4-fluorobenzoate in the USA?
ChemContract Research is a trusted USA-based supplier of Methyl 3-cyano-4-fluorobenzoate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Methyl 3-cyano-4-fluorobenzoate?
ChemContract Research supplies Methyl 3-cyano-4-fluorobenzoate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Methyl 3-cyano-4-fluorobenzoate in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Methyl 3-cyano-4-fluorobenzoate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in Methyl 3-cyano-4-fluorobenzoate?
The fluorine atom(s) in Methyl 3-cyano-4-fluorobenzoate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like Methyl 3-cyano-4-fluorobenzoate valuable in pharmaceutical development.
Can the nitrile group in Methyl 3-cyano-4-fluorobenzoate be converted to other functional groups?
Yes. The nitrile (–C≡N) in Methyl 3-cyano-4-fluorobenzoate can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
How should I store Methyl 3-cyano-4-fluorobenzoate?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Methyl 3-cyano-4-fluorobenzoate?
The CAS Registry Number for Methyl 3-cyano-4-fluorobenzoate is 676602-31-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
