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Methyl 2-(piperidin-4-yl)acetate

CAS 22223-49-0 · Piperidine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Piperidine

Methyl 2-(piperidin-4-yl)acetate

Esters PharmaceuticalCNS TherapeuticsMedicinal ChemistryResearchPolymerFine Chemical
CAS Number 22223-49-0
Category Piperidine · Ester
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About Methyl 2-(piperidin-4-yl)acetate

Methyl 2-(piperidin-4-yl)acetate (CAS Number: 22223-49-0) is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles featuring a Piperidine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The piperidine ring is the most common nitrogen heterocycle in FDA-approved drugs, appearing in over 70 marketed pharmaceuticals across CNS, cardiovascular, and oncology indications. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.

Primary applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require Methyl 2-(piperidin-4-yl)acetate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Piperidine
Functional Groups: Ester (–COOR)

Piperidine Applications & Target Industries

How Methyl 2-(piperidin-4-yl)acetate is used across pharmaceutical and cns therapeutics sectors

01

CNS drug scaffold (present in donepezil, methylphenidate, fentanyl class)

02

Prodrug development to mask carboxylic acids and improve membrane permeability

03

Conformationally-restricted amine for receptor binding optimization

04

Protecting group for hydroxyl functionalities (acetate, benzoate)

05

Spirocyclic and fused ring system construction for 3D drug design

06

Ring-opening polymerization monomer for biodegradable polymers

Target Industries: PharmaceuticalCNS TherapeuticsMedicinal ChemistryResearchPolymerFine Chemical

Methyl 2-(piperidin-4-yl)acetate Specifications

Detailed specifications for this piperidine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name Methyl 2-(piperidin-4-yl)acetate
Type Piperidine
Category Piperidine · Ester
Purity ≥95% (custom grades available)
Complexity Simple (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Piperidines

Handling Guidelines

Handle with standard precautions. Piperidine and some derivatives have strong amine odors. Use a fume hood. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.

Storage Conditions

Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container away from heat and open flame.

Why Buy Methyl 2-(piperidin-4-yl)acetate From ChemContract?

Quality Assured

Every batch of Methyl 2-(piperidin-4-yl)acetate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of Methyl 2-(piperidin-4-yl)acetate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about Methyl 2-(piperidin-4-yl)acetate

What is Methyl 2-(piperidin-4-yl)acetate used for? +

Methyl 2-(piperidin-4-yl)acetate is a piperidine-containing compound — one of the most drug-prevalent saturated N-heterocycles used primarily in the pharmaceutical and cns therapeutics industries. Key applications include cns drug scaffold (present in donepezil, methylphenidate, fentanyl class) and prodrug development to mask carboxylic acids and improve membrane permeability.

Where can I buy Methyl 2-(piperidin-4-yl)acetate in the USA? +

ChemContract Research is a trusted USA-based supplier of Methyl 2-(piperidin-4-yl)acetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for Methyl 2-(piperidin-4-yl)acetate? +

ChemContract Research supplies Methyl 2-(piperidin-4-yl)acetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize Methyl 2-(piperidin-4-yl)acetate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for Methyl 2-(piperidin-4-yl)acetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use Methyl 2-(piperidin-4-yl)acetate? +

The Piperidine ring system(s) in Methyl 2-(piperidin-4-yl)acetate is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store Methyl 2-(piperidin-4-yl)acetate? +

Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of Methyl 2-(piperidin-4-yl)acetate? +

The CAS Registry Number for Methyl 2-(piperidin-4-yl)acetate is 22223-49-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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