CAS 426-65-3 · Fluorinated Compound · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days
Ethyl pentafluoropropionate (CAS Number: 426-65-3) is a fluorine-containing building block with enhanced metabolic stability. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.
Primary applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, diagnostic imaging, agrochemical sectors. Whether you require Ethyl pentafluoropropionate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How Ethyl pentafluoropropionate is used across pharmaceutical and diagnostic imaging sectors
Metabolic blocking strategy — fluorine substitution to improve drug half-life
Prodrug development to mask carboxylic acids and improve membrane permeability
PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging
Protecting group for hydroxyl functionalities (acetate, benzoate)
Agrochemical synthesis for next-generation crop protection agents
Ring-opening polymerization monomer for biodegradable polymers
Detailed specifications for this fluorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame.
Fluorinated compounds require careful handling. We provide Ethyl pentafluoropropionate with verified fluorine content, stability data, and guidance on storage to prevent decomposition.
Every batch of Ethyl pentafluoropropionate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of Ethyl pentafluoropropionate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about Ethyl pentafluoropropionate
Ethyl pentafluoropropionate is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and prodrug development to mask carboxylic acids and improve membrane permeability.
ChemContract Research is a trusted USA-based supplier of Ethyl pentafluoropropionate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies Ethyl pentafluoropropionate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for Ethyl pentafluoropropionate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The fluorine atom(s) in Ethyl pentafluoropropionate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like Ethyl pentafluoropropionate valuable in pharmaceutical development.
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for Ethyl pentafluoropropionate is 426-65-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
Get competitive pricing, custom quantities, and fast USA delivery. Our chemistry team is standing by to provide specifications, CoA documentation, and a tailored quote for your project.
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