Frequently Asked
Common questions about Ethyl difluoro(iodo)acetate
What is Ethyl difluoro(iodo)acetate used for?
Ethyl difluoro(iodo)acetate is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and sonogashira and heck coupling with the lowest activation barrier among aryl halides.
Where can I buy Ethyl difluoro(iodo)acetate in the USA?
ChemContract Research is a trusted USA-based supplier of Ethyl difluoro(iodo)acetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Ethyl difluoro(iodo)acetate?
ChemContract Research supplies Ethyl difluoro(iodo)acetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Ethyl difluoro(iodo)acetate in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Ethyl difluoro(iodo)acetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in Ethyl difluoro(iodo)acetate?
The fluorine atom(s) in Ethyl difluoro(iodo)acetate confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like Ethyl difluoro(iodo)acetate valuable in pharmaceutical development.
What coupling reactions can I run with Ethyl difluoro(iodo)acetate?
As a iodinated compound, Ethyl difluoro(iodo)acetate is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store Ethyl difluoro(iodo)acetate?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Ethyl difluoro(iodo)acetate?
The CAS Registry Number for Ethyl difluoro(iodo)acetate is 7648-30-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
