CAS 28485-17-8 · Ketone · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate (CAS Number: 28485-17-8) is a ketone-containing compound with a carbonyl center flanked by carbon substituents featuring a Pyrimidine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Ketones serve as strategic intermediates in retrosynthetic planning — their carbonyl can be disconnected in multiple directions, providing flexible synthetic access to complex targets. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Hydroxyl groups are critical pharmacophores — they serve as hydrogen-bond donors and acceptors, influencing drug–target binding, aqueous solubility, and metabolic susceptibility.
Primary applications include asymmetric reduction to chiral alcohols using cbs or noyori catalysts and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate is used across pharmaceutical and fine chemical sectors
Asymmetric reduction to chiral alcohols using CBS or Noyori catalysts
Core scaffold in kinase inhibitor design for oncology therapeutics
Mitsunobu reaction substrate for stereospecific inversion at chiral centers
Grignard and organolithium additions for tertiary alcohol synthesis
GPCR modulator development for CNS and cardiovascular indications
Oxidation to aldehydes (Swern, Dess–Martin) or ketones for downstream chemistry
Detailed specifications for this ketone, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Handle with standard laboratory precautions. Some ketones are flammable. Use adequate ventilation and wear safety glasses and gloves. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Some alcohols are flammable. Use adequate ventilation and appropriate PPE.
Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container away from heat sources and oxidizers.
Every batch of Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate
Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate is a ketone-containing compound with a carbonyl center flanked by carbon substituents used primarily in the pharmaceutical and fine chemical industries. Key applications include asymmetric reduction to chiral alcohols using cbs or noyori catalysts and core scaffold in kinase inhibitor design for oncology therapeutics.
ChemContract Research is a trusted USA-based supplier of Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
The Pyrimidine ring system(s) in Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container away from heat sources and oxidizers. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for Ethyl 4-hydroxy-2-oxo-1,2-dihydropyrimidine-5-carboxylate is 28485-17-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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