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Ethyl 4-(1-piperazinyl)benzoate

CAS 80518-57-6 · Piperazine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Piperazine

Ethyl 4-(1-piperazinyl)benzoate

Esters PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryPolymerFine Chemical
CAS Number 80518-57-6
Category Piperazine · Ester
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About Ethyl 4-(1-piperazinyl)benzoate

Ethyl 4-(1-piperazinyl)benzoate (CAS Number: 80518-57-6) is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif featuring a Piperazine ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The two nitrogen atoms of piperazine provide both a basic amine (pKa ~9.8) for salt formation and a secondary amine (pKa ~5.3) for functionalization, giving medicinal chemists dual synthetic handles. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.

Primary applications include solubility enhancer via piperazine salt formation in drug formulation and prodrug development to mask carboxylic acids and improve membrane permeability. This compound serves researchers and manufacturers across the pharmaceutical, cns therapeutics, medicinal chemistry sectors. Whether you require Ethyl 4-(1-piperazinyl)benzoate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Piperazine
Functional Groups: Ester (–COOR)

Piperazine Applications & Target Industries

How Ethyl 4-(1-piperazinyl)benzoate is used across pharmaceutical and cns therapeutics sectors

01

Solubility enhancer via piperazine salt formation in drug formulation

02

Prodrug development to mask carboxylic acids and improve membrane permeability

03

Bioisosteric replacement for piperidine to improve metabolic profile

04

Protecting group for hydroxyl functionalities (acetate, benzoate)

05

Antipsychotic and anxiolytic drug scaffold (aripiprazole class)

06

Ring-opening polymerization monomer for biodegradable polymers

Target Industries: PharmaceuticalCNS TherapeuticsMedicinal ChemistryDrug DeliveryPolymerFine Chemical

Ethyl 4-(1-piperazinyl)benzoate Specifications

Detailed specifications for this piperazine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name Ethyl 4-(1-piperazinyl)benzoate
Type Piperazine
Category Piperazine · Ester
Purity ≥95% (custom grades available)
Complexity Simple (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Piperazines

Handling Guidelines

Handle with standard precautions. Some piperazine derivatives may be irritating. Use adequate ventilation. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.

Storage Conditions

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container away from heat and open flame.

Why Buy Ethyl 4-(1-piperazinyl)benzoate From ChemContract?

Quality Assured

Every batch of Ethyl 4-(1-piperazinyl)benzoate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of Ethyl 4-(1-piperazinyl)benzoate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about Ethyl 4-(1-piperazinyl)benzoate

What is Ethyl 4-(1-piperazinyl)benzoate used for? +

Ethyl 4-(1-piperazinyl)benzoate is a piperazine-containing compound used extensively as a pharmacokinetic-enhancing motif used primarily in the pharmaceutical and cns therapeutics industries. Key applications include solubility enhancer via piperazine salt formation in drug formulation and prodrug development to mask carboxylic acids and improve membrane permeability.

Where can I buy Ethyl 4-(1-piperazinyl)benzoate in the USA? +

ChemContract Research is a trusted USA-based supplier of Ethyl 4-(1-piperazinyl)benzoate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for Ethyl 4-(1-piperazinyl)benzoate? +

ChemContract Research supplies Ethyl 4-(1-piperazinyl)benzoate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize Ethyl 4-(1-piperazinyl)benzoate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for Ethyl 4-(1-piperazinyl)benzoate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use Ethyl 4-(1-piperazinyl)benzoate? +

The Piperazine ring system(s) in Ethyl 4-(1-piperazinyl)benzoate is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store Ethyl 4-(1-piperazinyl)benzoate? +

Store at room temperature in a tightly sealed container away from acids. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of Ethyl 4-(1-piperazinyl)benzoate? +

The CAS Registry Number for Ethyl 4-(1-piperazinyl)benzoate is 80518-57-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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