Frequently Asked
Common questions about Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester
What is Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester used for?
Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.
Where can I buy Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester in the USA?
ChemContract Research is a trusted USA-based supplier of Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester?
ChemContract Research supplies Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester in custom quantities?
Yes. ChemContract Research offers custom synthesis services for Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester?
For amide bond formation from the carboxylic acid in Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
Why is fluorine important in Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester?
The fluorine atom(s) in Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester valuable in pharmaceutical development.
How should I store Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester?
The CAS Registry Number for Cyclohexanecarboxylic acid, 4,4-difluoro-1-hydroxy-, ethyl ester is 1393824-30-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
