Search 7,000+ Chemicals

Start typing to search our catalog

Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile

CAS 5005-36-7 · Nitrile · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Nitrile

Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile

PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryAnalytical Chemistry
CAS Number 5005-36-7
Category Nitrile · Stereodefined Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile

Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile (CAS Number: 5005-36-7) is a nitrile-functionalized compound with a versatile C≡N triple bond featuring a Benzene ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The nitrile group is a bioisostere for both carboxylic acids and amides, and has emerged as a covalent warhead in next-generation kinase inhibitors like saxagliptin and neratinib. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.

Primary applications include hydrolysis to carboxylic acids or amides under controlled conditions and enantiopure building block for single-enantiomer drug development. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Nitrile (–C≡N)
Stereochemistry: Defined Configuration

Nitrile Applications & Target Industries

How Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile is used across pharmaceutical and fine chemical sectors

01

Hydrolysis to carboxylic acids or amides under controlled conditions

02

Enantiopure building block for single-enantiomer drug development

03

Click chemistry precursor for tetrazole formation (azide–nitrile cycloaddition)

04

Chiral resolution standard or chiral HPLC reference compound

05

Covalent-warhead cysteine-targeting moiety in kinase inhibitor design

06

Asymmetric synthesis substrate with defined stereochemistry

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryAnalytical Chemistry

Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile Specifications

Detailed specifications for this nitrile, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile
Type Nitrile
Category Nitrile · Stereodefined Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Nitriles

Handling Guidelines

Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile From ChemContract?

Quality Assured

Every batch of Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile

What is Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile used for? +

Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile is a nitrile-functionalized compound with a versatile C≡N triple bond used primarily in the pharmaceutical and fine chemical industries. Key applications include hydrolysis to carboxylic acids or amides under controlled conditions and enantiopure building block for single-enantiomer drug development.

Where can I buy Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile in the USA? +

ChemContract Research is a trusted USA-based supplier of Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile? +

ChemContract Research supplies Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What is the stereochemical purity of Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile? +

ChemContract Research supplies Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

Can the nitrile group in Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile be converted to other functional groups? +

Yes. The nitrile (–C≡N) in Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.

How should I store Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile? +

Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile? +

The CAS Registry Number for Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile is 5005-36-7. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

Get Alpha-Phenyl-Alpha-(2-Pyridyl)Acetonitrile Delivered This Week

Get competitive pricing, custom quantities, and fast USA delivery. Our chemistry team is standing by to provide specifications, CoA documentation, and a tailored quote for your project.

Or call us directly: +1 (714) 732-8549

ChemContract

Let's Build
Your Molecule

From discovery to commercial scale — our 500+ scientists are ready to accelerate your project.

24-Hour ResponseFast turnaround guaranteed
60+ FacilitiesGlobal R&D network
cGMP CompliantFDA-ready manufacturing

Request a Quote

Tell us about your compound and we'll send a detailed quote within 24 hours.

Contact Information
Chemical Specifications
ChemContract
Mon-Fri 8AM-5PM PT

Hi there! How can we help you today?