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8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )

CAS 156611-76-7 · Heterocyclic Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Heterocyclic Compound

8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )

Heterocycles PharmaceuticalMedicinal ChemistryAgrochemicalCatalysisCNS TherapeuticsResearch
CAS Number 156611-76-7
Category Heterocyclic Compound · Piperidine
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )

8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) (CAS Number: 156611-76-7) is a heterocycle-containing compound — the dominant scaffold class in approved pharmaceuticals featuring Pyridine, Piperidine ring systems with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. The piperidine ring is the most common nitrogen heterocycle in FDA-approved drugs, appearing in over 70 marketed pharmaceuticals across CNS, cardiovascular, and oncology indications. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include core scaffold in kinase inhibitor design for oncology therapeutics and cns drug scaffold (present in donepezil, methylphenidate, fentanyl class). This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: PyridinePiperidine
Functional Groups: Chlorine (C–Cl)
Stereochemistry: Defined Configuration
Salt Form: Hydrochloride

Heterocyclic Compound Applications & Target Industries

How 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) is used across pharmaceutical and medicinal chemistry sectors

01

Core scaffold in kinase inhibitor design for oncology therapeutics

02

CNS drug scaffold (present in donepezil, methylphenidate, fentanyl class)

03

Improved handling characteristics versus the free base form

04

Enantiopure building block for single-enantiomer drug development

05

GPCR modulator development for CNS and cardiovascular indications

06

Conformationally-restricted amine for receptor binding optimization

Target Industries: PharmaceuticalMedicinal ChemistryAgrochemicalCatalysisCNS TherapeuticsResearch

8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) Specifications

Detailed specifications for this heterocyclic compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )
Type Heterocyclic Compound
Category Heterocyclic Compound · Piperidine
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Salt Form Hydrochloride
Complexity Moderate (1 functional groups, 2 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Heterocyclic Compounds

Handling Guidelines

Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Piperidine and some derivatives have strong amine odors. Use a fume hood. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) From ChemContract?

Quality Assured

Every batch of 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )

What is 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) used for? +

8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) is a heterocycle-containing compound — the dominant scaffold class in approved pharmaceuticals used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include core scaffold in kinase inhibitor design for oncology therapeutics and cns drug scaffold (present in donepezil, methylphenidate, fentanyl class).

Where can I buy 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) in the USA? +

ChemContract Research is a trusted USA-based supplier of 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ). We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )? +

ChemContract Research supplies 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) in a different salt form or as the free base? +

Yes. ChemContract Research can supply 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What drug discovery applications use 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )? +

The Pyridine and Piperidine ring system(s) in 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )? +

Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )? +

The CAS Registry Number for 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) is 156611-76-7. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

Get 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride ) Delivered This Week

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