CAS 314267-78-2 · Ketone · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days
6-chloro-?-oxo-3-Pyridinepropanenitrile (CAS Number: 314267-78-2) is a ketone-containing compound with a carbonyl center flanked by carbon substituents featuring a Pyridine ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Ketones serve as strategic intermediates in retrosynthetic planning — their carbonyl can be disconnected in multiple directions, providing flexible synthetic access to complex targets. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.
Primary applications include asymmetric reduction to chiral alcohols using cbs or noyori catalysts and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 6-chloro-?-oxo-3-Pyridinepropanenitrile for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 6-chloro-?-oxo-3-Pyridinepropanenitrile is used across pharmaceutical and fine chemical sectors
Asymmetric reduction to chiral alcohols using CBS or Noyori catalysts
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Core scaffold in kinase inhibitor design for oncology therapeutics
Hydrolysis to carboxylic acids or amides under controlled conditions
Grignard and organolithium additions for tertiary alcohol synthesis
Grignard reagent precursor for C–C bond construction
Detailed specifications for this ketone, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Handle with standard laboratory precautions. Some ketones are flammable. Use adequate ventilation and wear safety glasses and gloves. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible.
Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases.
Every batch of 6-chloro-?-oxo-3-Pyridinepropanenitrile is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 6-chloro-?-oxo-3-Pyridinepropanenitrile? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 6-chloro-?-oxo-3-Pyridinepropanenitrile
6-chloro-?-oxo-3-Pyridinepropanenitrile is a ketone-containing compound with a carbonyl center flanked by carbon substituents used primarily in the pharmaceutical and fine chemical industries. Key applications include asymmetric reduction to chiral alcohols using cbs or noyori catalysts and nucleophilic aromatic substitution (snar) for ether and amine formation.
ChemContract Research is a trusted USA-based supplier of 6-chloro-?-oxo-3-Pyridinepropanenitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 6-chloro-?-oxo-3-Pyridinepropanenitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 6-chloro-?-oxo-3-Pyridinepropanenitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Yes. The nitrile (–C≡N) in 6-chloro-?-oxo-3-Pyridinepropanenitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
As a chlorinated compound, 6-chloro-?-oxo-3-Pyridinepropanenitrile is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Store at room temperature in a tightly sealed container. Protect from direct sunlight and heat sources. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 6-chloro-?-oxo-3-Pyridinepropanenitrile is 314267-78-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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