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5-fluorothiazol-2-amine hydrochloride

CAS 745053-64-9 · Amine · 5 functional traits · cGMP compliant · Ships from USA in 2-3 days

Amine

5-fluorothiazol-2-amine hydrochloride

Fluorinated PharmaceuticalPolymerAgrochemicalCatalysisDiagnostic ImagingMaterials Science
CAS Number 745053-64-9
Category Amine · Fluorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 5-fluorothiazol-2-amine hydrochloride

5-fluorothiazol-2-amine hydrochloride (CAS Number: 745053-64-9) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Thiazole ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.

Primary applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require 5-fluorothiazol-2-amine hydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Thiazole
Functional Groups: Amine (–NH₂/–NHR)Fluorine (C–F)Chlorine (C–Cl)
Stereochemistry: Defined Configuration
Salt Form: Hydrochloride

Amine Applications & Target Industries

How 5-fluorothiazol-2-amine hydrochloride is used across pharmaceutical and polymer sectors

01

Buchwald–Hartwig amination for aryl C–N bond construction

02

Metabolic blocking strategy — fluorine substitution to improve drug half-life

03

Core scaffold in kinase inhibitor design for oncology therapeutics

04

Improved handling characteristics versus the free base form

05

Enantiopure building block for single-enantiomer drug development

06

Reductive amination with aldehydes and ketones for secondary amine synthesis

Target Industries: PharmaceuticalPolymerAgrochemicalCatalysisDiagnostic ImagingMaterials Science

5-fluorothiazol-2-amine hydrochloride Specifications

Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 5-fluorothiazol-2-amine hydrochloride
Type Amine
Category Amine · Fluorinated Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Salt Form Hydrochloride
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Amines

Handling Guidelines

Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 5-fluorothiazol-2-amine hydrochloride From ChemContract?

Quality Assured

Every batch of 5-fluorothiazol-2-amine hydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 5-fluorothiazol-2-amine hydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 5-fluorothiazol-2-amine hydrochloride

What is 5-fluorothiazol-2-amine hydrochloride used for? +

5-fluorothiazol-2-amine hydrochloride is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.

Where can I buy 5-fluorothiazol-2-amine hydrochloride in the USA? +

ChemContract Research is a trusted USA-based supplier of 5-fluorothiazol-2-amine hydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 5-fluorothiazol-2-amine hydrochloride? +

ChemContract Research supplies 5-fluorothiazol-2-amine hydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 5-fluorothiazol-2-amine hydrochloride in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 5-fluorothiazol-2-amine hydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can I get 5-fluorothiazol-2-amine hydrochloride in a different salt form or as the free base? +

Yes. ChemContract Research can supply 5-fluorothiazol-2-amine hydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

What reactions can I perform with the amine group in 5-fluorothiazol-2-amine hydrochloride? +

The amine functionality in 5-fluorothiazol-2-amine hydrochloride enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.

How should I store 5-fluorothiazol-2-amine hydrochloride? +

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 5-fluorothiazol-2-amine hydrochloride? +

The CAS Registry Number for 5-fluorothiazol-2-amine hydrochloride is 745053-64-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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