5-Chlorothiophene-2-sulfonic acid tert-butylamide

5-Chlorothiophene-2-sulfonic acid tert-butylamide is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and nucleophilic aromatic substitution (snar) for ether and amine formation.

ChemContract Research is a trusted USA-based supplier of 5-Chlorothiophene-2-sulfonic acid tert-butylamide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

ChemContract Research supplies 5-Chlorothiophene-2-sulfonic acid tert-butylamide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Yes. ChemContract Research offers custom synthesis services for 5-Chlorothiophene-2-sulfonic acid tert-butylamide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

For amide bond formation from the carboxylic acid in 5-Chlorothiophene-2-sulfonic acid tert-butylamide, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.

As a chlorinated compound, 5-Chlorothiophene-2-sulfonic acid tert-butylamide is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

The CAS Registry Number for 5-Chlorothiophene-2-sulfonic acid tert-butylamide is 155731-14-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.