CAS 60367-52-4 · Aldehyde · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde (CAS Number: 60367-52-4) is an aldehyde with a highly electrophilic carbonyl group featuring a Benzene ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
The aldehyde carbonyl is one of the most reactive electrophilic centers in organic chemistry, enabling diverse transformations from imine formation to asymmetric allylation. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.
Primary applications include reductive amination for c–n bond formation in api synthesis and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, fragrance & flavor, fine chemical sectors. Whether you require 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde is used across pharmaceutical and fragrance & flavor sectors
Reductive amination for C–N bond formation in API synthesis
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Enantiopure building block for single-enantiomer drug development
Wittig and Horner–Wadsworth–Emmons olefination substrates
Grignard reagent precursor for C–C bond construction
Chiral resolution standard or chiral HPLC reference compound
Detailed specifications for this aldehyde, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Aldehydes can be irritating to skin, eyes, and respiratory tract. Handle in a well-ventilated fume hood. Many are volatile and flammable. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.
Store at recommended temperature under inert atmosphere. Protect from air to prevent oxidation to the corresponding carboxylic acid. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.
Every batch of 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde
5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde is an aldehyde with a highly electrophilic carbonyl group used primarily in the pharmaceutical and fragrance & flavor industries. Key applications include reductive amination for c–n bond formation in api synthesis and nucleophilic aromatic substitution (snar) for ether and amine formation.
ChemContract Research is a trusted USA-based supplier of 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a chlorinated compound, 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
ChemContract Research supplies 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.
Store at recommended temperature under inert atmosphere. Protect from air to prevent oxidation to the corresponding carboxylic acid. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 5-chloro-2-phenyl-1H-imiadazole-4-carbaldehyde is 60367-52-4. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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