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5-Bromoindole-2-carboxylic acid ethyl ester

CAS 16732-70-0 · Brominated Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Brominated Compound

5-Bromoindole-2-carboxylic acid ethyl ester

Heterocycles PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryCatalysis
CAS Number 16732-70-0
Category Brominated Compound · Heterocyclic Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 5-Bromoindole-2-carboxylic acid ethyl ester

5-Bromoindole-2-carboxylic acid ethyl ester (CAS Number: 16732-70-0) is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling featuring a Indole ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step.

Primary applications include grignard reagent preparation via magnesium insertion into c–br bond and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 5-Bromoindole-2-carboxylic acid ethyl ester for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Indole
Functional Groups: Carboxylic acid (–COOH)Ester (–COOR)Bromine (C–Br)

Brominated Compound Applications & Target Industries

How 5-Bromoindole-2-carboxylic acid ethyl ester is used across pharmaceutical and fine chemical sectors

01

Grignard reagent preparation via magnesium insertion into C–Br bond

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

04

Prodrug development to mask carboxylic acids and improve membrane permeability

05

Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling

06

GPCR modulator development for CNS and cardiovascular indications

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchMedicinal ChemistryCatalysis

5-Bromoindole-2-carboxylic acid ethyl ester Specifications

Detailed specifications for this brominated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 5-Bromoindole-2-carboxylic acid ethyl ester
Type Brominated Compound
Category Brominated Compound · Heterocyclic Compound
Purity ≥95% (custom grades available)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Brominated Compounds

Handling Guidelines

Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.

Storage Conditions

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame.

Why Buy 5-Bromoindole-2-carboxylic acid ethyl ester From ChemContract?

Quality Assured

Every batch of 5-Bromoindole-2-carboxylic acid ethyl ester is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 5-Bromoindole-2-carboxylic acid ethyl ester? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 5-Bromoindole-2-carboxylic acid ethyl ester

What is 5-Bromoindole-2-carboxylic acid ethyl ester used for? +

5-Bromoindole-2-carboxylic acid ethyl ester is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 5-Bromoindole-2-carboxylic acid ethyl ester in the USA? +

ChemContract Research is a trusted USA-based supplier of 5-Bromoindole-2-carboxylic acid ethyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 5-Bromoindole-2-carboxylic acid ethyl ester? +

ChemContract Research supplies 5-Bromoindole-2-carboxylic acid ethyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 5-Bromoindole-2-carboxylic acid ethyl ester in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 5-Bromoindole-2-carboxylic acid ethyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use 5-Bromoindole-2-carboxylic acid ethyl ester? +

The Indole ring system(s) in 5-Bromoindole-2-carboxylic acid ethyl ester is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

What coupling reactions can I run with 5-Bromoindole-2-carboxylic acid ethyl ester? +

As a brominated compound, 5-Bromoindole-2-carboxylic acid ethyl ester is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 5-Bromoindole-2-carboxylic acid ethyl ester? +

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 5-Bromoindole-2-carboxylic acid ethyl ester? +

The CAS Registry Number for 5-Bromoindole-2-carboxylic acid ethyl ester is 16732-70-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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