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5-Bromo-4-chloro-3-indolyl acetate

CAS 3252-36-6 · Brominated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Brominated Compound

5-Bromo-4-chloro-3-indolyl acetate

Halogenated PharmaceuticalFine ChemicalAgrochemicalResearchChemical ManufacturingPolymer
CAS Number 3252-36-6
Category Brominated Compound · Chlorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 5-Bromo-4-chloro-3-indolyl acetate

5-Bromo-4-chloro-3-indolyl acetate (CAS Number: 3252-36-6) is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling featuring a Indole ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.

Primary applications include grignard reagent preparation via magnesium insertion into c–br bond and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 5-Bromo-4-chloro-3-indolyl acetate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Indole
Functional Groups: Ester (–COOR)Bromine (C–Br)Chlorine (C–Cl)

Brominated Compound Applications & Target Industries

How 5-Bromo-4-chloro-3-indolyl acetate is used across pharmaceutical and fine chemical sectors

01

Grignard reagent preparation via magnesium insertion into C–Br bond

02

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

03

Prodrug development to mask carboxylic acids and improve membrane permeability

04

Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling

05

Grignard reagent precursor for C–C bond construction

06

Protecting group for hydroxyl functionalities (acetate, benzoate)

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchChemical ManufacturingPolymer

5-Bromo-4-chloro-3-indolyl acetate Specifications

Detailed specifications for this brominated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 5-Bromo-4-chloro-3-indolyl acetate
Type Brominated Compound
Category Brominated Compound · Chlorinated Compound
Purity ≥95% (custom grades available)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Brominated Compounds

Handling Guidelines

Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.

Storage Conditions

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame.

Why Buy 5-Bromo-4-chloro-3-indolyl acetate From ChemContract?

Quality Assured

Every batch of 5-Bromo-4-chloro-3-indolyl acetate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 5-Bromo-4-chloro-3-indolyl acetate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 5-Bromo-4-chloro-3-indolyl acetate

What is 5-Bromo-4-chloro-3-indolyl acetate used for? +

5-Bromo-4-chloro-3-indolyl acetate is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and nucleophilic aromatic substitution (snar) for ether and amine formation.

Where can I buy 5-Bromo-4-chloro-3-indolyl acetate in the USA? +

ChemContract Research is a trusted USA-based supplier of 5-Bromo-4-chloro-3-indolyl acetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 5-Bromo-4-chloro-3-indolyl acetate? +

ChemContract Research supplies 5-Bromo-4-chloro-3-indolyl acetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 5-Bromo-4-chloro-3-indolyl acetate in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 5-Bromo-4-chloro-3-indolyl acetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What coupling reactions can I run with 5-Bromo-4-chloro-3-indolyl acetate? +

As a brominated compound, 5-Bromo-4-chloro-3-indolyl acetate is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 5-Bromo-4-chloro-3-indolyl acetate? +

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 5-Bromo-4-chloro-3-indolyl acetate? +

The CAS Registry Number for 5-Bromo-4-chloro-3-indolyl acetate is 3252-36-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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