CAS 3252-36-6 · Brominated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
5-Bromo-4-chloro-3-indolyl acetate (CAS Number: 3252-36-6) is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling featuring a Indole ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.
Primary applications include grignard reagent preparation via magnesium insertion into c–br bond and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 5-Bromo-4-chloro-3-indolyl acetate for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 5-Bromo-4-chloro-3-indolyl acetate is used across pharmaceutical and fine chemical sectors
Grignard reagent preparation via magnesium insertion into C–Br bond
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Prodrug development to mask carboxylic acids and improve membrane permeability
Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling
Grignard reagent precursor for C–C bond construction
Protecting group for hydroxyl functionalities (acetate, benzoate)
Detailed specifications for this brominated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources.
Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame.
Aryl and alkyl bromides like 5-Bromo-4-chloro-3-indolyl acetate are optimized for cross-coupling. We verify halide integrity and provide Pd-catalyst compatibility data on request.
Every batch of 5-Bromo-4-chloro-3-indolyl acetate is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 5-Bromo-4-chloro-3-indolyl acetate? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 5-Bromo-4-chloro-3-indolyl acetate
5-Bromo-4-chloro-3-indolyl acetate is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and nucleophilic aromatic substitution (snar) for ether and amine formation.
ChemContract Research is a trusted USA-based supplier of 5-Bromo-4-chloro-3-indolyl acetate. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 5-Bromo-4-chloro-3-indolyl acetate in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 5-Bromo-4-chloro-3-indolyl acetate from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a brominated compound, 5-Bromo-4-chloro-3-indolyl acetate is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 5-Bromo-4-chloro-3-indolyl acetate is 3252-36-6. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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