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4,6-Dichloro-2-propylthiopyrimidine-5-amine

CAS 145783-15-9 · Amine · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Amine

4,6-Dichloro-2-propylthiopyrimidine-5-amine

Heterocycles PharmaceuticalPolymerAgrochemicalCatalysisFine ChemicalChemical Manufacturing
CAS Number 145783-15-9
Category Amine · Chlorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4,6-Dichloro-2-propylthiopyrimidine-5-amine

4,6-Dichloro-2-propylthiopyrimidine-5-amine (CAS Number: 145783-15-9) is an amine-functionalized compound with nucleophilic nitrogen reactivity featuring a Pyrimidine ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.

Primary applications include buchwald–hartwig amination for aryl c–n bond construction and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require 4,6-Dichloro-2-propylthiopyrimidine-5-amine for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Pyrimidine
Functional Groups: Amine (–NH₂/–NHR)Chlorine (C–Cl)Thioether (C–S–C)

Amine Applications & Target Industries

How 4,6-Dichloro-2-propylthiopyrimidine-5-amine is used across pharmaceutical and polymer sectors

01

Buchwald–Hartwig amination for aryl C–N bond construction

02

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

03

Core scaffold in kinase inhibitor design for oncology therapeutics

04

Reductive amination with aldehydes and ketones for secondary amine synthesis

05

Grignard reagent precursor for C–C bond construction

06

GPCR modulator development for CNS and cardiovascular indications

Target Industries: PharmaceuticalPolymerAgrochemicalCatalysisFine ChemicalChemical Manufacturing

4,6-Dichloro-2-propylthiopyrimidine-5-amine Specifications

Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4,6-Dichloro-2-propylthiopyrimidine-5-amine
Type Amine
Category Amine · Chlorinated Compound
Purity ≥95% (custom grades available)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Amines

Handling Guidelines

Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation.

Storage Conditions

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive.

Why Buy 4,6-Dichloro-2-propylthiopyrimidine-5-amine From ChemContract?

Quality Assured

Every batch of 4,6-Dichloro-2-propylthiopyrimidine-5-amine is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4,6-Dichloro-2-propylthiopyrimidine-5-amine? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4,6-Dichloro-2-propylthiopyrimidine-5-amine

What is 4,6-Dichloro-2-propylthiopyrimidine-5-amine used for? +

4,6-Dichloro-2-propylthiopyrimidine-5-amine is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and nucleophilic aromatic substitution (snar) for ether and amine formation.

Where can I buy 4,6-Dichloro-2-propylthiopyrimidine-5-amine in the USA? +

ChemContract Research is a trusted USA-based supplier of 4,6-Dichloro-2-propylthiopyrimidine-5-amine. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4,6-Dichloro-2-propylthiopyrimidine-5-amine? +

ChemContract Research supplies 4,6-Dichloro-2-propylthiopyrimidine-5-amine in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4,6-Dichloro-2-propylthiopyrimidine-5-amine in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4,6-Dichloro-2-propylthiopyrimidine-5-amine from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use 4,6-Dichloro-2-propylthiopyrimidine-5-amine? +

The Pyrimidine ring system(s) in 4,6-Dichloro-2-propylthiopyrimidine-5-amine is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

What coupling reactions can I run with 4,6-Dichloro-2-propylthiopyrimidine-5-amine? +

As a chlorinated compound, 4,6-Dichloro-2-propylthiopyrimidine-5-amine is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 4,6-Dichloro-2-propylthiopyrimidine-5-amine? +

Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4,6-Dichloro-2-propylthiopyrimidine-5-amine? +

The CAS Registry Number for 4,6-Dichloro-2-propylthiopyrimidine-5-amine is 145783-15-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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