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4-(Trifluoromethoxy)phenylhydrazine hydrochloride

CAS 133115-72-7 · Hydrazine Derivative · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Hydrazine Derivative

4-(Trifluoromethoxy)phenylhydrazine hydrochloride

Fluorinated PharmaceuticalAgrochemicalFine ChemicalAnalytical ChemistryDiagnostic ImagingMaterials Science
CAS Number 133115-72-7
Category Hydrazine Derivative · Fluorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-(Trifluoromethoxy)phenylhydrazine hydrochloride

4-(Trifluoromethoxy)phenylhydrazine hydrochloride (CAS Number: 133115-72-7) is a hydrazine-containing compound used as a versatile nitrogen nucleophile featuring a Benzene ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The N–N bond in hydrazines provides unique reactivity for heterocycle formation and is a key motif in several FDA-approved drugs including celecoxib and crizotinib analogs. The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones and metabolic blocking strategy — fluorine substitution to improve drug half-life. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 4-(Trifluoromethoxy)phenylhydrazine hydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Fluorine (C–F)Chlorine (C–Cl)Alkoxy (–OR)
Salt Form: Hydrochloride

Hydrazine Derivative Applications & Target Industries

How 4-(Trifluoromethoxy)phenylhydrazine hydrochloride is used across pharmaceutical and agrochemical sectors

01

Synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones

02

Metabolic blocking strategy — fluorine substitution to improve drug half-life

03

Improved handling characteristics versus the free base form

04

Formation of hydrazones as carbonyl protecting groups and analytical probes

05

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

06

Direct formulation excipient in oral solid dosage forms

Target Industries: PharmaceuticalAgrochemicalFine ChemicalAnalytical ChemistryDiagnostic ImagingMaterials Science

4-(Trifluoromethoxy)phenylhydrazine hydrochloride Specifications

Detailed specifications for this hydrazine derivative, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-(Trifluoromethoxy)phenylhydrazine hydrochloride
Type Hydrazine Derivative
Category Hydrazine Derivative · Fluorinated Compound
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Hydrazine Derivatives

Handling Guidelines

Hydrazine derivatives may be toxic and potentially sensitizing. Always work in a well-ventilated fume hood with chemical-resistant gloves, safety goggles, and a lab coat. Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store refrigerated (2–8 °C) in a tightly sealed container. Protect from light, heat, and oxidizing agents. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy 4-(Trifluoromethoxy)phenylhydrazine hydrochloride From ChemContract?

Quality Assured

Every batch of 4-(Trifluoromethoxy)phenylhydrazine hydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-(Trifluoromethoxy)phenylhydrazine hydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-(Trifluoromethoxy)phenylhydrazine hydrochloride

What is 4-(Trifluoromethoxy)phenylhydrazine hydrochloride used for? +

4-(Trifluoromethoxy)phenylhydrazine hydrochloride is a hydrazine-containing compound used as a versatile nitrogen nucleophile used primarily in the pharmaceutical and agrochemical industries. Key applications include synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones and metabolic blocking strategy — fluorine substitution to improve drug half-life.

Where can I buy 4-(Trifluoromethoxy)phenylhydrazine hydrochloride in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-(Trifluoromethoxy)phenylhydrazine hydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-(Trifluoromethoxy)phenylhydrazine hydrochloride? +

ChemContract Research supplies 4-(Trifluoromethoxy)phenylhydrazine hydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-(Trifluoromethoxy)phenylhydrazine hydrochloride in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-(Trifluoromethoxy)phenylhydrazine hydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Why is fluorine important in 4-(Trifluoromethoxy)phenylhydrazine hydrochloride? +

The fluorine atom(s) in 4-(Trifluoromethoxy)phenylhydrazine hydrochloride confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 4-(Trifluoromethoxy)phenylhydrazine hydrochloride valuable in pharmaceutical development.

Can I get 4-(Trifluoromethoxy)phenylhydrazine hydrochloride in a different salt form or as the free base? +

Yes. ChemContract Research can supply 4-(Trifluoromethoxy)phenylhydrazine hydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

How should I store 4-(Trifluoromethoxy)phenylhydrazine hydrochloride? +

Store refrigerated (2–8 °C) in a tightly sealed container. Protect from light, heat, and oxidizing agents. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-(Trifluoromethoxy)phenylhydrazine hydrochloride? +

The CAS Registry Number for 4-(Trifluoromethoxy)phenylhydrazine hydrochloride is 133115-72-7. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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