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4-Pyridyl Acetonitrile Hcl

CAS 92333-25-0 · Nitrile · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Nitrile

4-Pyridyl Acetonitrile Hcl

PharmaceuticalFine ChemicalAgrochemicalResearchFormulationAnalytical Chemistry
CAS Number 92333-25-0
Category Nitrile · Hydrochloride Salt
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-Pyridyl Acetonitrile Hcl

4-Pyridyl Acetonitrile Hcl (CAS Number: 92333-25-0) is a nitrile-functionalized compound with a versatile C≡N triple bond. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The nitrile group is a bioisostere for both carboxylic acids and amides, and has emerged as a covalent warhead in next-generation kinase inhibitors like saxagliptin and neratinib. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.

Primary applications include hydrolysis to carboxylic acids or amides under controlled conditions and improved handling characteristics versus the free base form. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 4-Pyridyl Acetonitrile Hcl for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Functional Groups: Nitrile (–C≡N)
Salt Form: Hydrochloride

Nitrile Applications & Target Industries

How 4-Pyridyl Acetonitrile Hcl is used across pharmaceutical and fine chemical sectors

01

Hydrolysis to carboxylic acids or amides under controlled conditions

02

Improved handling characteristics versus the free base form

03

Click chemistry precursor for tetrazole formation (azide–nitrile cycloaddition)

04

Direct formulation excipient in oral solid dosage forms

05

Covalent-warhead cysteine-targeting moiety in kinase inhibitor design

06

Crystalline form screening for polymorph and salt studies

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchFormulationAnalytical Chemistry

4-Pyridyl Acetonitrile Hcl Specifications

Detailed specifications for this nitrile, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-Pyridyl Acetonitrile Hcl
Type Nitrile
Category Nitrile · Hydrochloride Salt
Purity ≥95% (custom grades available)
Salt Form Hydrochloride
Complexity Simple (1 functional groups, 0 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Nitriles

Handling Guidelines

Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.

Storage Conditions

Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store at room temperature in a tightly sealed container. Protect from humidity.

Why Buy 4-Pyridyl Acetonitrile Hcl From ChemContract?

Quality Assured

Every batch of 4-Pyridyl Acetonitrile Hcl is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-Pyridyl Acetonitrile Hcl? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-Pyridyl Acetonitrile Hcl

What is 4-Pyridyl Acetonitrile Hcl used for? +

4-Pyridyl Acetonitrile Hcl is a nitrile-functionalized compound with a versatile C≡N triple bond used primarily in the pharmaceutical and fine chemical industries. Key applications include hydrolysis to carboxylic acids or amides under controlled conditions and improved handling characteristics versus the free base form.

Where can I buy 4-Pyridyl Acetonitrile Hcl in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-Pyridyl Acetonitrile Hcl. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-Pyridyl Acetonitrile Hcl? +

ChemContract Research supplies 4-Pyridyl Acetonitrile Hcl in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-Pyridyl Acetonitrile Hcl in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-Pyridyl Acetonitrile Hcl from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Can the nitrile group in 4-Pyridyl Acetonitrile Hcl be converted to other functional groups? +

Yes. The nitrile (–C≡N) in 4-Pyridyl Acetonitrile Hcl can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.

Can I get 4-Pyridyl Acetonitrile Hcl in a different salt form or as the free base? +

Yes. ChemContract Research can supply 4-Pyridyl Acetonitrile Hcl as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.

How should I store 4-Pyridyl Acetonitrile Hcl? +

Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-Pyridyl Acetonitrile Hcl? +

The CAS Registry Number for 4-Pyridyl Acetonitrile Hcl is 92333-25-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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Get competitive pricing, custom quantities, and fast USA delivery. Our chemistry team is standing by to provide specifications, CoA documentation, and a tailored quote for your project.

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