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4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%

CAS 1208170-17-5 · Chlorinated Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Chlorinated Compound

4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%

Heterocycles PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingMedicinal ChemistryCatalysis
CAS Number 1208170-17-5
Category Chlorinated Compound · Heterocyclic Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%

4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% (CAS Number: 1208170-17-5) is a chloro-substituted intermediate widely used in nucleophilic displacement reactions featuring a Pyrimidine ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. The nitrile group is a bioisostere for both carboxylic acids and amides, and has emerged as a covalent warhead in next-generation kinase inhibitors like saxagliptin and neratinib.

Primary applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Pyrimidine
Functional Groups: Nitrile (–C≡N)Chlorine (C–Cl)Thioether (C–S–C)
Stereochemistry: Defined Configuration

Chlorinated Compound Applications & Target Industries

How 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% is used across pharmaceutical and agrochemical sectors

01

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Hydrolysis to carboxylic acids or amides under controlled conditions

04

Enantiopure building block for single-enantiomer drug development

05

Grignard reagent precursor for C–C bond construction

06

GPCR modulator development for CNS and cardiovascular indications

Target Industries: PharmaceuticalAgrochemicalFine ChemicalChemical ManufacturingMedicinal ChemistryCatalysis

4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% Specifications

Detailed specifications for this chlorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%
Type Chlorinated Compound
Category Chlorinated Compound · Heterocyclic Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Chlorinated Compounds

Handling Guidelines

Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% From ChemContract?

Quality Assured

Every batch of 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%

What is 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% used for? +

4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? +

ChemContract Research supplies 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What is the stereochemical purity of 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? +

ChemContract Research supplies 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

What drug discovery applications use 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? +

The Pyrimidine ring system(s) in 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

How should I store 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? +

Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95%? +

The CAS Registry Number for 4-Chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile >95% is 1208170-17-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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