Frequently Asked
Common questions about 4-chloro-2,3-difluorobenzoic acid,
What is 4-chloro-2,3-difluorobenzoic acid, used for?
4-chloro-2,3-difluorobenzoic acid, is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and nucleophilic aromatic substitution (snar) for ether and amine formation.
Where can I buy 4-chloro-2,3-difluorobenzoic acid, in the USA?
ChemContract Research is a trusted USA-based supplier of 4-chloro-2,3-difluorobenzoic acid,. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 4-chloro-2,3-difluorobenzoic acid,?
ChemContract Research supplies 4-chloro-2,3-difluorobenzoic acid, in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 4-chloro-2,3-difluorobenzoic acid, in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 4-chloro-2,3-difluorobenzoic acid, from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reagents work best with 4-chloro-2,3-difluorobenzoic acid,?
For amide bond formation from the carboxylic acid in 4-chloro-2,3-difluorobenzoic acid,, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
What coupling reactions can I run with 4-chloro-2,3-difluorobenzoic acid,?
As a chlorinated compound, 4-chloro-2,3-difluorobenzoic acid, is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
How should I store 4-chloro-2,3-difluorobenzoic acid,?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 4-chloro-2,3-difluorobenzoic acid,?
The CAS Registry Number for 4-chloro-2,3-difluorobenzoic acid, is 150444-94-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
