Frequently Asked
Common questions about 4-Chloro-2-iodobenzoic acid
What is 4-Chloro-2-iodobenzoic acid used for?
4-Chloro-2-iodobenzoic acid is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and sonogashira and heck coupling with the lowest activation barrier among aryl halides.
Where can I buy 4-Chloro-2-iodobenzoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of 4-Chloro-2-iodobenzoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 4-Chloro-2-iodobenzoic acid?
ChemContract Research supplies 4-Chloro-2-iodobenzoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 4-Chloro-2-iodobenzoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 4-Chloro-2-iodobenzoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
What coupling reactions can I run with 4-Chloro-2-iodobenzoic acid?
As a chlorinated compound, 4-Chloro-2-iodobenzoic acid is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
What coupling reagents work best with 4-Chloro-2-iodobenzoic acid?
For amide bond formation from the carboxylic acid in 4-Chloro-2-iodobenzoic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How should I store 4-Chloro-2-iodobenzoic acid?
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 4-Chloro-2-iodobenzoic acid?
The CAS Registry Number for 4-Chloro-2-iodobenzoic acid is 13421-13-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
