CAS 52807-27-9 · Chlorinated Compound · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days
4-Chloro-2-iodoanisole (CAS Number: 52807-27-9) is a chloro-substituted intermediate widely used in nucleophilic displacement reactions. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. The C–I bond is the weakest carbon–halogen bond, which translates to the highest reactivity in oxidative addition — making aryl iodides the first-choice substrate for challenging cross-coupling reactions.
Primary applications include nucleophilic aromatic substitution (snar) for ether and amine formation and sonogashira and heck coupling with the lowest activation barrier among aryl halides. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 4-Chloro-2-iodoanisole for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 4-Chloro-2-iodoanisole is used across pharmaceutical and agrochemical sectors
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Sonogashira and Heck coupling with the lowest activation barrier among aryl halides
Grignard reagent precursor for C–C bond construction
Radioiodination precursor for SPECT and PET diagnostic imaging
Acyl chloride reactivity for amide and ester formation
Metal–halogen exchange with n-BuLi for directed metalation strategies
Detailed specifications for this chlorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Iodo compounds may be light-sensitive and can stain skin. Handle in a fume hood and protect from light during use.
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation.
Every batch of 4-Chloro-2-iodoanisole is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 4-Chloro-2-iodoanisole? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 4-Chloro-2-iodoanisole
4-Chloro-2-iodoanisole is a chloro-substituted intermediate widely used in nucleophilic displacement reactions used primarily in the pharmaceutical and agrochemical industries. Key applications include nucleophilic aromatic substitution (snar) for ether and amine formation and sonogashira and heck coupling with the lowest activation barrier among aryl halides.
ChemContract Research is a trusted USA-based supplier of 4-Chloro-2-iodoanisole. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 4-Chloro-2-iodoanisole in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 4-Chloro-2-iodoanisole from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a chlorinated compound, 4-Chloro-2-iodoanisole is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store refrigerated (2–8 °C) in a light-resistant, tightly sealed container under inert atmosphere to prevent degradation. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 4-Chloro-2-iodoanisole is 52807-27-9. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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