CAS 622-88-8 · Hydrazine Derivative · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
4-Bromophenylhydrazinehydrochloride (CAS Number: 622-88-8) is a hydrazine-containing compound used as a versatile nitrogen nucleophile featuring a Benzene ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.
The N–N bond in hydrazines provides unique reactivity for heterocycle formation and is a key motif in several FDA-approved drugs including celecoxib and crizotinib analogs. Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Hydrochloride is the most common salt form for basic drug substances — approximately half of all salt-form drugs on the market are HCl salts, valued for their crystallinity and aqueous solubility.
Primary applications include synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones and grignard reagent preparation via magnesium insertion into c–br bond. This compound serves researchers and manufacturers across the pharmaceutical, agrochemical, fine chemical sectors. Whether you require 4-Bromophenylhydrazinehydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 4-Bromophenylhydrazinehydrochloride is used across pharmaceutical and agrochemical sectors
Synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones
Grignard reagent preparation via magnesium insertion into C–Br bond
Improved handling characteristics versus the free base form
Formation of hydrazones as carbonyl protecting groups and analytical probes
Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling
Direct formulation excipient in oral solid dosage forms
Detailed specifications for this hydrazine derivative, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Hydrazine derivatives may be toxic and potentially sensitizing. Always work in a well-ventilated fume hood with chemical-resistant gloves, safety goggles, and a lab coat. Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases.
Store refrigerated (2–8 °C) in a tightly sealed container. Protect from light, heat, and oxidizing agents. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at room temperature in a tightly sealed container. Protect from humidity.
Every batch of 4-Bromophenylhydrazinehydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 4-Bromophenylhydrazinehydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 4-Bromophenylhydrazinehydrochloride
4-Bromophenylhydrazinehydrochloride is a hydrazine-containing compound used as a versatile nitrogen nucleophile used primarily in the pharmaceutical and agrochemical industries. Key applications include synthesis of pyrazole and pyridazine heterocycles from 1,3-diketones and grignard reagent preparation via magnesium insertion into c–br bond.
ChemContract Research is a trusted USA-based supplier of 4-Bromophenylhydrazinehydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 4-Bromophenylhydrazinehydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 4-Bromophenylhydrazinehydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a brominated compound, 4-Bromophenylhydrazinehydrochloride is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
Yes. ChemContract Research can supply 4-Bromophenylhydrazinehydrochloride as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Hydrochloride form.
Store refrigerated (2–8 °C) in a tightly sealed container. Protect from light, heat, and oxidizing agents. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at room temperature in a tightly sealed container. Protect from humidity. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 4-Bromophenylhydrazinehydrochloride is 622-88-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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