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4-Bromophenylboronic acid

CAS 5467-74-3 · Boronic Acid / Boronate Ester · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days

Boronic Acid / Boronate Ester

4-Bromophenylboronic acid

Boronic Acids PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalFine ChemicalResearch
CAS Number 5467-74-3
Category Boronic Acid / Boronate Ester · Brominated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-Bromophenylboronic acid

4-Bromophenylboronic acid (CAS Number: 5467-74-3) is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions featuring a Benzene ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The boron atom in this compound enables transmetalation with palladium catalysts, making it a cornerstone reagent for Suzuki coupling — one of the most widely used reactions in pharmaceutical process chemistry. Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry.

Primary applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and grignard reagent preparation via magnesium insertion into c–br bond. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, diagnostics sectors. Whether you require 4-Bromophenylboronic acid for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Boronic acidCarboxylic acid (–COOH)Bromine (C–Br)

Boronic Acid / Boronate Ester Applications & Target Industries

How 4-Bromophenylboronic acid is used across pharmaceutical and medicinal chemistry sectors

01

Suzuki–Miyaura cross-coupling for biaryl and heterobiaryl synthesis

02

Grignard reagent preparation via magnesium insertion into C–Br bond

03

Proteasome inhibitor design in oncology drug development

04

Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling

05

Saccharide and diol sensor development for diagnostic applications

06

Nucleophilic substitution (SN2) for C–N, C–O, and C–S bond formation

Target Industries: PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalFine ChemicalResearch

4-Bromophenylboronic acid Specifications

Detailed specifications for this boronic acid / boronate ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-Bromophenylboronic acid
Type Boronic Acid / Boronate Ester
Category Boronic Acid / Boronate Ester · Brominated Compound
Purity ≥95% (custom grades available)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Boronic Acid / Boronate Esters

Handling Guidelines

Boronic acids are generally air-stable but some may be moisture-sensitive and undergo protodeboronation. Handle with gloves and safety glasses. Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE.

Storage Conditions

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration.

Why Buy 4-Bromophenylboronic acid From ChemContract?

Quality Assured

Every batch of 4-Bromophenylboronic acid is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-Bromophenylboronic acid? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-Bromophenylboronic acid

What is 4-Bromophenylboronic acid used for? +

4-Bromophenylboronic acid is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and grignard reagent preparation via magnesium insertion into c–br bond.

Where can I buy 4-Bromophenylboronic acid in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-Bromophenylboronic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-Bromophenylboronic acid? +

ChemContract Research supplies 4-Bromophenylboronic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-Bromophenylboronic acid in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-Bromophenylboronic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What cross-coupling reactions can I use 4-Bromophenylboronic acid in? +

4-Bromophenylboronic acid is primarily used in Suzuki–Miyaura cross-coupling reactions with aryl or vinyl halides under palladium catalysis. This reaction forms C–C bonds with excellent functional group tolerance and mild conditions. It can also be used in Chan–Lam coupling for C–N and C–O bond formation without transition metal catalysts under aerobic conditions.

What coupling reactions can I run with 4-Bromophenylboronic acid? +

As a brominated compound, 4-Bromophenylboronic acid is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 4-Bromophenylboronic acid? +

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-Bromophenylboronic acid? +

The CAS Registry Number for 4-Bromophenylboronic acid is 5467-74-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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