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4-Bromomethylbiphenyl-2-carboxylic acid methyl ester

CAS 114772-38-2 · Brominated Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Brominated Compound

4-Bromomethylbiphenyl-2-carboxylic acid methyl ester

Halogenated PharmaceuticalFine ChemicalAgrochemicalResearchPolymerGreen Chemistry
CAS Number 114772-38-2
Category Brominated Compound · Carboxylic Acid
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester

4-Bromomethylbiphenyl-2-carboxylic acid methyl ester (CAS Number: 114772-38-2) is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling featuring a Benzene ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Aryl and alkyl bromides occupy a "Goldilocks zone" in cross-coupling — more reactive than chlorides yet more stable than iodides — making them the most commonly used coupling partners in process chemistry. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step. Ester hydrolysis by cellular esterases is the most commonly exploited prodrug activation mechanism — enabling drugs that cannot cross biological membranes as free acids.

Primary applications include grignard reagent preparation via magnesium insertion into c–br bond and amide bond formation via edc/hobt or hatu coupling in peptide synthesis. This compound serves researchers and manufacturers across the pharmaceutical, fine chemical, agrochemical sectors. Whether you require 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Benzene
Functional Groups: Carboxylic acid (–COOH)Ester (–COOR)Bromine (C–Br)
Stereochemistry: Defined Configuration

Brominated Compound Applications & Target Industries

How 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester is used across pharmaceutical and fine chemical sectors

01

Grignard reagent preparation via magnesium insertion into C–Br bond

02

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

03

Prodrug development to mask carboxylic acids and improve membrane permeability

04

Enantiopure building block for single-enantiomer drug development

05

Palladium-catalyzed Suzuki, Heck, and Negishi cross-coupling

06

Salt formation with amines to improve drug crystallinity and stability

Target Industries: PharmaceuticalFine ChemicalAgrochemicalResearchPolymerGreen Chemistry

4-Bromomethylbiphenyl-2-carboxylic acid methyl ester Specifications

Detailed specifications for this brominated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester
Type Brominated Compound
Category Brominated Compound · Carboxylic Acid
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Brominated Compounds

Handling Guidelines

Some brominated compounds may be lachrymatory or skin irritants. Handle in a fume hood with appropriate PPE. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. Some esters are volatile and flammable. Handle in a well-ventilated area. Keep away from ignition sources. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester From ChemContract?

Quality Assured

Every batch of 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester

What is 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester used for? +

4-Bromomethylbiphenyl-2-carboxylic acid methyl ester is a bromo-substituted intermediate prized for its reactivity in metal-catalyzed coupling used primarily in the pharmaceutical and fine chemical industries. Key applications include grignard reagent preparation via magnesium insertion into c–br bond and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.

Where can I buy 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? +

ChemContract Research supplies 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What is the stereochemical purity of 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? +

ChemContract Research supplies 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

What coupling reactions can I run with 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? +

As a brominated compound, 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? +

Store at room temperature in a tightly sealed, light-resistant container. Some bromo compounds require refrigeration. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store at room temperature in a tightly sealed container away from heat and open flame. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester? +

The CAS Registry Number for 4-Bromomethylbiphenyl-2-carboxylic acid methyl ester is 114772-38-2. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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