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4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)

CAS 1523606-35-0 · Fluorinated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Fluorinated Compound

4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)

Fluorinated PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical
CAS Number 1523606-35-0
Category Fluorinated Compound · Carboxylic Acid
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)

4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) (CAS Number: 1523606-35-0) is a fluorine-containing building block with enhanced metabolic stability featuring Morpholine, Azetidine ring systems. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the trifluoroacetate salt form for enhanced stability and handling.

The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Carboxylic acids are among the most synthetically versatile functional groups — they can be converted to amides, esters, acid chlorides, anhydrides, alcohols, and aldehydes in a single step. TFA salts are the default isolation form for amines purified by reversed-phase HPLC or deprotected from Boc groups. Salt exchange to HCl or free base is typically required before biological testing.

Primary applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and amide bond formation via edc/hobt or hatu coupling in peptide synthesis. This compound serves researchers and manufacturers across the pharmaceutical, diagnostic imaging, agrochemical sectors. Whether you require 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: MorpholineAzetidine
Functional Groups: Carboxylic acid (–COOH)Fluorine (C–F)
Salt Form: Trifluoroacetate

Fluorinated Compound Applications & Target Industries

How 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) is used across pharmaceutical and diagnostic imaging sectors

01

Metabolic blocking strategy — fluorine substitution to improve drug half-life

02

Amide bond formation via EDC/HOBt or HATU coupling in peptide synthesis

03

Commonly isolated form from Boc deprotection in peptide synthesis

04

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

05

Salt formation with amines to improve drug crystallinity and stability

06

TFA salt-to-free-base or HCl salt conversion for formulation development

Target Industries: PharmaceuticalDiagnostic ImagingAgrochemicalMaterials SciencePolymerFine Chemical

4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) Specifications

Detailed specifications for this fluorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)
Type Fluorinated Compound
Category Fluorinated Compound · Carboxylic Acid
Purity ≥95% (custom grades available)
Salt Form Trifluoroacetate
Complexity Moderate (2 functional groups, 2 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Fluorinated Compounds

Handling Guidelines

Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Acids may be corrosive or irritating. Handle with chemical-resistant gloves and eye protection. Use a fume hood for volatile acids. TFA salts are hygroscopic. Handle in a dry environment. TFA is corrosive — wear chemical-resistant gloves.

Storage Conditions

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence.

Why Buy 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) From ChemContract?

Quality Assured

Every batch of 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)

What is 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) used for? +

4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and amide bond formation via edc/hobt or hatu coupling in peptide synthesis.

Where can I buy 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid). We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)? +

ChemContract Research supplies 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

Why is fluorine important in 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)? +

The fluorine atom(s) in 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) valuable in pharmaceutical development.

Can I get 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) in a different salt form or as the free base? +

Yes. ChemContract Research can supply 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) as the free base or convert it to alternative salt forms including hydrochloride, mesylate, tosylate, fumarate, or other pharmaceutically acceptable counter-ions. Salt form selection impacts crystallinity, stability, and solubility — our chemistry team can advise on optimal salt selection for your application. Currently supplied as the Trifluoroacetate form.

How should I store 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)? +

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Store desiccated at –20 °C or as recommended. Protect from moisture to prevent deliquescence. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid)? +

The CAS Registry Number for 4-(azetidin-3-yl)-2,2-dimethylmorpholine; bis(trifluoroacetic acid) is 1523606-35-0. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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