Frequently Asked
Common questions about 4-Amino-3-fluorobenzoic acid
What is 4-Amino-3-fluorobenzoic acid used for?
4-Amino-3-fluorobenzoic acid is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and metabolic blocking strategy — fluorine substitution to improve drug half-life.
Where can I buy 4-Amino-3-fluorobenzoic acid in the USA?
ChemContract Research is a trusted USA-based supplier of 4-Amino-3-fluorobenzoic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 4-Amino-3-fluorobenzoic acid?
ChemContract Research supplies 4-Amino-3-fluorobenzoic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 4-Amino-3-fluorobenzoic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 4-Amino-3-fluorobenzoic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in 4-Amino-3-fluorobenzoic acid?
The fluorine atom(s) in 4-Amino-3-fluorobenzoic acid confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 4-Amino-3-fluorobenzoic acid valuable in pharmaceutical development.
What reactions can I perform with the amine group in 4-Amino-3-fluorobenzoic acid?
The amine functionality in 4-Amino-3-fluorobenzoic acid enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
How should I store 4-Amino-3-fluorobenzoic acid?
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 4-Amino-3-fluorobenzoic acid?
The CAS Registry Number for 4-Amino-3-fluorobenzoic acid is 455-87-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
