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4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride

Boronic Acid / Boronate Ester · 5 functional traits · cGMP compliant · Ships from USA in 2-3 days

Boronic Acid / Boronate Ester

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride

Sulfonyl PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalPolymerCNS Therapeutics
Category Boronic Acid / Boronate Ester · Sulfur-Containing Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions featuring Piperidine, Benzene, Dioxaborolane (Pinacol boronate) ring systems with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States. Supplied as the hydrochloride salt form for enhanced stability and handling.

The boron atom in this compound enables transmetalation with palladium catalysts, making it a cornerstone reagent for Suzuki coupling — one of the most widely used reactions in pharmaceutical process chemistry. Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. The piperidine ring is the most common nitrogen heterocycle in FDA-approved drugs, appearing in over 70 marketed pharmaceuticals across CNS, cardiovascular, and oncology indications.

Primary applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and sulfonamide pharmacophore installation for antibiotic and diuretic development. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, diagnostics sectors. Whether you require 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: PiperidineBenzeneDioxaborolane (Pinacol boronate)
Functional Groups: Chlorine (C–Cl)
Stereochemistry: Defined Configuration
Salt Form: Hydrochloride

Boronic Acid / Boronate Ester Applications & Target Industries

How 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride is used across pharmaceutical and medicinal chemistry sectors

01

Suzuki–Miyaura cross-coupling for biaryl and heterobiaryl synthesis

02

Sulfonamide pharmacophore installation for antibiotic and diuretic development

03

CNS drug scaffold (present in donepezil, methylphenidate, fentanyl class)

04

Improved handling characteristics versus the free base form

05

Enantiopure building block for single-enantiomer drug development

06

Proteasome inhibitor design in oncology drug development

Target Industries: PharmaceuticalMedicinal ChemistryDiagnosticsAgrochemicalPolymerCNS Therapeutics

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride Specifications

Detailed specifications for this boronic acid / boronate ester, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride
Type Boronic Acid / Boronate Ester
Category Boronic Acid / Boronate Ester · Sulfur-Containing Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Salt Form Hydrochloride
Complexity Moderate (1 functional groups, 3 rings)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Boronic Acid / Boronate Esters

Handling Guidelines

Boronic acids are generally air-stable but some may be moisture-sensitive and undergo protodeboronation. Handle with gloves and safety glasses. Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Handle with standard precautions. Piperidine and some derivatives have strong amine odors. Use a fume hood. Handle with standard precautions. Hydrochloride salts are generally more stable than free bases. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride From ChemContract?

Quality Assured

Every batch of 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride

What is 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride used for? +

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride is a boronic acid derivative valued for its role in carbon–carbon bond-forming reactions used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include suzuki–miyaura cross-coupling for biaryl and heterobiaryl synthesis and sulfonamide pharmacophore installation for antibiotic and diuretic development.

Where can I buy 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride in the USA? +

ChemContract Research is a trusted USA-based supplier of 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride? +

ChemContract Research supplies 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What cross-coupling reactions can I use 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride in? +

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride is primarily used in Suzuki–Miyaura cross-coupling reactions with aryl or vinyl halides under palladium catalysis. This reaction forms C–C bonds with excellent functional group tolerance and mild conditions. It can also be used in Chan–Lam coupling for C–N and C–O bond formation without transition metal catalysts under aerobic conditions.

What is the stereochemical purity of 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride? +

ChemContract Research supplies 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride? +

Store in a tightly sealed container at room temperature under dry conditions. Protect from prolonged moisture exposure. Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at room temperature in a well-sealed container. Some N-unsubstituted piperidines are volatile. Store at room temperature in a tightly sealed container. Protect from humidity. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

Get 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperidine hydrochloride Delivered This Week

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