CAS 80466-79-1 · Sulfur-Containing Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days
3,5-Dimethylisoxazole-4-sulfonyl chloride (CAS Number: 80466-79-1) is a sulfur-functionalized compound with diverse reactivity featuring a Oxazole ring. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.
Primary applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require 3,5-Dimethylisoxazole-4-sulfonyl chloride for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 3,5-Dimethylisoxazole-4-sulfonyl chloride is used across pharmaceutical and medicinal chemistry sectors
Sulfonamide pharmacophore installation for antibiotic and diuretic development
Nucleophilic aromatic substitution (SNAr) for ether and amine formation
Core scaffold in kinase inhibitor design for oncology therapeutics
Tosyl and mesyl protecting groups for hydroxyl and amine functionalities
Grignard reagent precursor for C–C bond construction
GPCR modulator development for CNS and cardiovascular indications
Detailed specifications for this sulfur-containing compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive.
Every batch of 3,5-Dimethylisoxazole-4-sulfonyl chloride is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 3,5-Dimethylisoxazole-4-sulfonyl chloride? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 3,5-Dimethylisoxazole-4-sulfonyl chloride
3,5-Dimethylisoxazole-4-sulfonyl chloride is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and nucleophilic aromatic substitution (snar) for ether and amine formation.
ChemContract Research is a trusted USA-based supplier of 3,5-Dimethylisoxazole-4-sulfonyl chloride. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 3,5-Dimethylisoxazole-4-sulfonyl chloride in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 3,5-Dimethylisoxazole-4-sulfonyl chloride from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
As a chlorinated compound, 3,5-Dimethylisoxazole-4-sulfonyl chloride is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.
The Oxazole ring system(s) in 3,5-Dimethylisoxazole-4-sulfonyl chloride is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.
Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 3,5-Dimethylisoxazole-4-sulfonyl chloride is 80466-79-1. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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