CAS 17626-40-3 · Amine · 2 functional traits · cGMP compliant · Ships from USA in 2-3 days
3,4-Diaminobenzonitrile (CAS Number: 17626-40-3) is an amine-functionalized compound with nucleophilic nitrogen reactivity. ChemContract Research supplies this simple-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.
Amines are among the most prevalent functional groups in drug molecules — over 80% of small-molecule pharmaceuticals contain at least one amine moiety. The nitrile group is a bioisostere for both carboxylic acids and amides, and has emerged as a covalent warhead in next-generation kinase inhibitors like saxagliptin and neratinib.
Primary applications include buchwald–hartwig amination for aryl c–n bond construction and hydrolysis to carboxylic acids or amides under controlled conditions. This compound serves researchers and manufacturers across the pharmaceutical, polymer, agrochemical sectors. Whether you require 3,4-Diaminobenzonitrile for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.
How 3,4-Diaminobenzonitrile is used across pharmaceutical and polymer sectors
Buchwald–Hartwig amination for aryl C–N bond construction
Hydrolysis to carboxylic acids or amides under controlled conditions
Reductive amination with aldehydes and ketones for secondary amine synthesis
Click chemistry precursor for tetrazole formation (azide–nitrile cycloaddition)
Salt formation to improve drug solubility and bioavailability
Covalent-warhead cysteine-targeting moiety in kinase inhibitor design
Detailed specifications for this amine, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:
Amines may have strong odors and can be corrosive to skin. Handle under adequate ventilation with chemical-resistant gloves and eye protection. Some nitriles may release HCN upon decomposition. Handle in a well-ventilated fume hood with a cyanide antidote kit accessible.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases.
Amines are the most prevalent pharmacophore in drug molecules. 3,4-Diaminobenzonitrile is supplied with salt-form options and free-base conversion protocols.
Every batch of 3,4-Diaminobenzonitrile is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.
Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.
Need a specific grade, quantity, or derivative of 3,4-Diaminobenzonitrile? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.
Common questions about 3,4-Diaminobenzonitrile
3,4-Diaminobenzonitrile is an amine-functionalized compound with nucleophilic nitrogen reactivity used primarily in the pharmaceutical and polymer industries. Key applications include buchwald–hartwig amination for aryl c–n bond construction and hydrolysis to carboxylic acids or amides under controlled conditions.
ChemContract Research is a trusted USA-based supplier of 3,4-Diaminobenzonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
ChemContract Research supplies 3,4-Diaminobenzonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Yes. ChemContract Research offers custom synthesis services for 3,4-Diaminobenzonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Yes. The nitrile (–C≡N) in 3,4-Diaminobenzonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
The amine functionality in 3,4-Diaminobenzonitrile enables diverse transformations: reductive amination with aldehydes/ketones, acylation to form amides, sulfonylation to form sulfonamides, Buchwald–Hartwig coupling with aryl halides, urea and carbamate formation, and salt generation for improved drug properties. The nucleophilicity of the nitrogen makes it one of the most versatile handles in synthetic chemistry.
Store in a cool, well-ventilated area away from acids and oxidizing agents. Keep containers tightly sealed as many amines are hygroscopic. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
The CAS Registry Number for 3,4-Diaminobenzonitrile is 17626-40-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
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