Frequently Asked
Common questions about {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid
What is {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid used for?
{[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid is a phosphorus-containing reagent with applications spanning catalysis and synthesis used primarily in the pharmaceutical and catalysis industries. Key applications include wittig and hwe olefination for stereoselective alkene synthesis and metabolic blocking strategy — fluorine substitution to improve drug half-life.
Where can I buy {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid in the USA?
ChemContract Research is a trusted USA-based supplier of {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid?
ChemContract Research supplies {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid in custom quantities?
Yes. ChemContract Research offers custom synthesis services for {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Why is fluorine important in {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid?
The fluorine atom(s) in {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid valuable in pharmaceutical development.
What coupling reagents work best with {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid?
For amide bond formation from the carboxylic acid in {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid, HATU/DIPEA is recommended for peptide coupling (high yield, low epimerization). EDC/HOBt is a cost-effective alternative for non-peptide amides. T3P (propylphosphonic acid anhydride) offers excellent atom economy with easy workup. For ester formation, DCC/DMAP (Steglich conditions) or Mitsunobu conditions are standard.
How should I store {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid?
Store under recommended conditions. Air-sensitive phosphines require inert-gas storage with Schlenk-line techniques. Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at room temperature in a tightly sealed container. Protect from moisture and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid?
The CAS Registry Number for {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid is 146780-09-8. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
