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3-Trifluoromethyl-1H-indole

CAS 51310-55-5 · Fluorinated Compound · 3 functional traits · cGMP compliant · Ships from USA in 2-3 days

Fluorinated Compound

3-Trifluoromethyl-1H-indole

Fluorinated PharmaceuticalDiagnostic ImagingAgrochemicalMaterials ScienceMedicinal ChemistryCatalysis
CAS Number 51310-55-5
Category Fluorinated Compound · Heterocyclic Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 3-Trifluoromethyl-1H-indole

3-Trifluoromethyl-1H-indole (CAS Number: 51310-55-5) is a fluorine-containing building block with enhanced metabolic stability featuring a Indole ring with defined stereochemistry. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

The carbon–fluorine bond is the strongest single bond to carbon (485 kJ/mol). This exceptional stability underpins the "fluorine scan" strategy used in medicinal chemistry to optimize drug candidates. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility. Chirality matters profoundly in drug action — enantiomers can differ by orders of magnitude in potency, and FDA guidelines increasingly require single-enantiomer development.

Primary applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and core scaffold in kinase inhibitor design for oncology therapeutics. This compound serves researchers and manufacturers across the pharmaceutical, diagnostic imaging, agrochemical sectors. Whether you require 3-Trifluoromethyl-1H-indole for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Indole
Functional Groups: Fluorine (C–F)
Stereochemistry: Defined Configuration

Fluorinated Compound Applications & Target Industries

How 3-Trifluoromethyl-1H-indole is used across pharmaceutical and diagnostic imaging sectors

01

Metabolic blocking strategy — fluorine substitution to improve drug half-life

02

Core scaffold in kinase inhibitor design for oncology therapeutics

03

Enantiopure building block for single-enantiomer drug development

04

PET radiotracer precursor ([¹⁸F]-labeling) for diagnostic imaging

05

GPCR modulator development for CNS and cardiovascular indications

06

Chiral resolution standard or chiral HPLC reference compound

Target Industries: PharmaceuticalDiagnostic ImagingAgrochemicalMaterials ScienceMedicinal ChemistryCatalysis

3-Trifluoromethyl-1H-indole Specifications

Detailed specifications for this fluorinated compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 3-Trifluoromethyl-1H-indole
Type Fluorinated Compound
Category Fluorinated Compound · Heterocyclic Compound
Purity ≥95% (custom grades available)
Stereochemistry Defined configuration (chiral HPLC verified)
Complexity Moderate (1 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Fluorinated Compounds

Handling Guidelines

Handle with care in a well-ventilated fume hood. Some fluorinated compounds may release HF upon decomposition. Use chemical-resistant gloves. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard precautions. Ensure proper labeling of stereochemical identity to prevent mix-ups.

Storage Conditions

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base.

Why Buy 3-Trifluoromethyl-1H-indole From ChemContract?

Quality Assured

Every batch of 3-Trifluoromethyl-1H-indole is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 3-Trifluoromethyl-1H-indole? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 3-Trifluoromethyl-1H-indole

What is 3-Trifluoromethyl-1H-indole used for? +

3-Trifluoromethyl-1H-indole is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and core scaffold in kinase inhibitor design for oncology therapeutics.

Where can I buy 3-Trifluoromethyl-1H-indole in the USA? +

ChemContract Research is a trusted USA-based supplier of 3-Trifluoromethyl-1H-indole. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 3-Trifluoromethyl-1H-indole? +

ChemContract Research supplies 3-Trifluoromethyl-1H-indole in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 3-Trifluoromethyl-1H-indole in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 3-Trifluoromethyl-1H-indole from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use 3-Trifluoromethyl-1H-indole? +

The Indole ring system(s) in 3-Trifluoromethyl-1H-indole is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

What is the stereochemical purity of 3-Trifluoromethyl-1H-indole? +

ChemContract Research supplies 3-Trifluoromethyl-1H-indole with verified enantiomeric or diastereomeric purity as documented in our Certificate of Analysis (CoA). Chiral HPLC analysis is standard for stereodefined compounds. We can provide material with ≥98% ee/de for demanding applications. Contact us for specific optical purity requirements.

How should I store 3-Trifluoromethyl-1H-indole? +

Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store under recommended conditions. Some chiral compounds may racemize at elevated temperatures or in the presence of base. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 3-Trifluoromethyl-1H-indole? +

The CAS Registry Number for 3-Trifluoromethyl-1H-indole is 51310-55-5. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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