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3-Pyridine-4-Chloro Sulfonamide

CAS 33263-43-3 · Sulfur-Containing Compound · 4 functional traits · cGMP compliant · Ships from USA in 2-3 days

Sulfur-Containing Compound

3-Pyridine-4-Chloro Sulfonamide

Sulfonyl PharmaceuticalMedicinal ChemistryAgrochemicalPolymerFine ChemicalChemical Manufacturing
CAS Number 33263-43-3
Category Sulfur-Containing Compound · Chlorinated Compound
Origin USA
Compliance cGMP

Questions? Contact our chemistry team:

chemistry@chem-contract.com | +1 (714) 732-8549
In stock — typically ships within 2-3 business days

About 3-Pyridine-4-Chloro Sulfonamide

3-Pyridine-4-Chloro Sulfonamide (CAS Number: 33263-43-3) is a sulfur-functionalized compound with diverse reactivity featuring a Pyridine ring. ChemContract Research supplies this moderate-complexity compound in high purity from our Huntington Beach, California facility, ensuring consistent quality and reliable domestic delivery throughout the United States.

Sulfonamides are one of the oldest and most successful pharmacophores in medicinal chemistry — present in antibiotics, diuretics, COX-2 inhibitors, and HIV protease inhibitors. Chloro substituents serve a dual role in drug design — as synthetic handles for late-stage functionalization and as bioisosteres that modulate lipophilicity and binding affinity. Heterocyclic rings appear in approximately 85% of all biologically active compounds. The nitrogen, oxygen, or sulfur heteroatom modulates electron density, hydrogen bonding, and aqueous solubility.

Primary applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and nucleophilic aromatic substitution (snar) for ether and amine formation. This compound serves researchers and manufacturers across the pharmaceutical, medicinal chemistry, agrochemical sectors. Whether you require 3-Pyridine-4-Chloro Sulfonamide for early-stage research, process development, or commercial-scale production, ChemContract Research offers flexible ordering from milligram to multi-kilogram quantities with custom synthesis options and full batch documentation including Certificates of Analysis (CoA) and Safety Data Sheets.

Ring Systems: Pyridine
Functional Groups: Amide (–CONH–)Chlorine (C–Cl)Sulfonamide (–SO₂NH–)

Sulfur-Containing Compound Applications & Target Industries

How 3-Pyridine-4-Chloro Sulfonamide is used across pharmaceutical and medicinal chemistry sectors

01

Sulfonamide pharmacophore installation for antibiotic and diuretic development

02

Nucleophilic aromatic substitution (SNAr) for ether and amine formation

03

Core scaffold in kinase inhibitor design for oncology therapeutics

04

Peptide bond mimetic for peptidomimetic drug design

05

Tosyl and mesyl protecting groups for hydroxyl and amine functionalities

06

Grignard reagent precursor for C–C bond construction

Target Industries: PharmaceuticalMedicinal ChemistryAgrochemicalPolymerFine ChemicalChemical Manufacturing

3-Pyridine-4-Chloro Sulfonamide Specifications

Detailed specifications for this sulfur-containing compound, including purity, molecular weight, and analytical data are available upon request. Every batch from ChemContract Research includes:

  • Certificate of Analysis (CoA) with purity verification
  • HPLC, NMR, and/or mass spectrometry characterization data
  • Material Safety Data Sheet (MSDS/SDS)
  • Batch-specific documentation and lot traceability
  • Custom analytical testing available on request
Request Full Specifications

Quick Reference

Compound Name 3-Pyridine-4-Chloro Sulfonamide
Type Sulfur-Containing Compound
Category Sulfur-Containing Compound · Chlorinated Compound
Purity ≥95% (custom grades available)
Complexity Moderate (3 functional groups, 1 ring)
Compliance cGMP
Packaging mg to kg scale

Storage & Handling for Sulfur-Containing Compounds

Handling Guidelines

Some sulfur compounds have strong odors. Handle in a well-ventilated fume hood. Consult the SDS for compound-specific hazards. Some chlorinated compounds are volatile or irritating. Use a fume hood and appropriate PPE. Acid chlorides react vigorously with water. Handle with standard laboratory precautions. Some heterocycles may be hygroscopic or irritating. Use adequate ventilation. Handle with standard laboratory precautions. Consult the SDS for compound-specific hazards.

Storage Conditions

Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature or as specified. Keep tightly sealed and protect from moisture.

Why Buy 3-Pyridine-4-Chloro Sulfonamide From ChemContract?

Quality Assured

Every batch of 3-Pyridine-4-Chloro Sulfonamide is produced under cGMP conditions with full CoA documentation, HPLC purity verification, and lot traceability.

Fast USA Shipping

Ship from our Huntington Beach, CA facility with 2-3 business day domestic delivery. No import delays, no customs fees, no tariff surprises.

Custom Synthesis

Need a specific grade, quantity, or derivative of 3-Pyridine-4-Chloro Sulfonamide? Our team of PhD chemists can develop custom synthesis solutions for your exact requirements.

Frequently Asked

Common questions about 3-Pyridine-4-Chloro Sulfonamide

What is 3-Pyridine-4-Chloro Sulfonamide used for? +

3-Pyridine-4-Chloro Sulfonamide is a sulfur-functionalized compound with diverse reactivity used primarily in the pharmaceutical and medicinal chemistry industries. Key applications include sulfonamide pharmacophore installation for antibiotic and diuretic development and nucleophilic aromatic substitution (snar) for ether and amine formation.

Where can I buy 3-Pyridine-4-Chloro Sulfonamide in the USA? +

ChemContract Research is a trusted USA-based supplier of 3-Pyridine-4-Chloro Sulfonamide. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.

What purity levels are available for 3-Pyridine-4-Chloro Sulfonamide? +

ChemContract Research supplies 3-Pyridine-4-Chloro Sulfonamide in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.

Can ChemContract synthesize 3-Pyridine-4-Chloro Sulfonamide in custom quantities? +

Yes. ChemContract Research offers custom synthesis services for 3-Pyridine-4-Chloro Sulfonamide from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.

What drug discovery applications use 3-Pyridine-4-Chloro Sulfonamide? +

The Pyridine ring system(s) in 3-Pyridine-4-Chloro Sulfonamide is a privileged structure in medicinal chemistry, appearing in numerous FDA-approved drugs. This scaffold is commonly used in kinase inhibitor design, GPCR modulator development, and lead optimization programs. ChemContract supplies this building block for early-stage discovery through process-scale manufacturing.

What coupling reactions can I run with 3-Pyridine-4-Chloro Sulfonamide? +

As a chlorinated compound, 3-Pyridine-4-Chloro Sulfonamide is an excellent substrate for palladium-catalyzed cross-coupling reactions including Suzuki, Heck, Negishi, Sonogashira, and Buchwald–Hartwig amination. It can also be used for Grignard reagent preparation, metal–halogen exchange with organolithium reagents, and nucleophilic substitution reactions.

How should I store 3-Pyridine-4-Chloro Sulfonamide? +

Store in a cool, dry place in a tightly sealed container. Protect from moisture and light as specified. Store at recommended temperature in a well-sealed container. Protect from moisture and strong bases. Store at recommended temperature in a tightly sealed container. Some heterocyclic compounds are light-sensitive. Store at room temperature or as specified. Keep tightly sealed and protect from moisture. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.

What is the CAS number of 3-Pyridine-4-Chloro Sulfonamide? +

The CAS Registry Number for 3-Pyridine-4-Chloro Sulfonamide is 33263-43-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.

Chemical analysis laboratory with HPLC instruments for purity and impurity testing Custom chemical synthesis reaction setup for pharmaceutical intermediate production

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