Frequently Asked
Common questions about 3-fluorocyclobutane-1-carbonitrile
What is 3-fluorocyclobutane-1-carbonitrile used for?
3-fluorocyclobutane-1-carbonitrile is a fluorine-containing building block with enhanced metabolic stability used primarily in the pharmaceutical and diagnostic imaging industries. Key applications include metabolic blocking strategy — fluorine substitution to improve drug half-life and hydrolysis to carboxylic acids or amides under controlled conditions.
Where can I buy 3-fluorocyclobutane-1-carbonitrile in the USA?
ChemContract Research is a trusted USA-based supplier of 3-fluorocyclobutane-1-carbonitrile. We offer competitive pricing, fast domestic shipping from our Huntington Beach, California facility, and full quality documentation including Certificates of Analysis (CoA). Request a quote at chemistry@chem-contract.com or call +1 (714) 732-8549.
What purity levels are available for 3-fluorocyclobutane-1-carbonitrile?
ChemContract Research supplies 3-fluorocyclobutane-1-carbonitrile in multiple purity grades: ≥95% standard grade, ≥97% high-purity grade, and ≥99% ultra-high-purity grade depending on application requirements. We can also provide custom purity grades through our synthesis capabilities. Contact us for specific purity information and CoA documentation.
Can ChemContract synthesize 3-fluorocyclobutane-1-carbonitrile in custom quantities?
Yes. ChemContract Research offers custom synthesis services for 3-fluorocyclobutane-1-carbonitrile from milligram to multi-kilogram scale. Our cGMP-compliant facilities and experienced chemists can accommodate custom specifications, packaging requirements, and delivery timelines. Contact our team to discuss your project.
Can the nitrile group in 3-fluorocyclobutane-1-carbonitrile be converted to other functional groups?
Yes. The nitrile (–C≡N) in 3-fluorocyclobutane-1-carbonitrile can be hydrolyzed to a carboxylic acid (strong acid/base, heat) or to an amide (milder conditions, e.g., H₂O₂/base). It can be reduced to a primary amine (LiAlH₄ or catalytic hydrogenation), converted to a tetrazole via [3+2] cycloaddition with NaN₃, or used in Grignard additions to form ketones after hydrolysis.
Why is fluorine important in 3-fluorocyclobutane-1-carbonitrile?
The fluorine atom(s) in 3-fluorocyclobutane-1-carbonitrile confer several advantages in drug design: increased metabolic stability due to the strong C–F bond (485 kJ/mol), enhanced lipophilicity for improved membrane permeability, and potential for favorable electrostatic interactions with biological targets. These properties make fluorinated compounds like 3-fluorocyclobutane-1-carbonitrile valuable in pharmaceutical development.
How should I store 3-fluorocyclobutane-1-carbonitrile?
Store at recommended temperature in a tightly sealed container. Protect from moisture, heat, and incompatible materials. Store in a cool, dry, well-ventilated area. Keep tightly sealed and away from acids and strong bases. Always consult the compound-specific Safety Data Sheet (SDS) provided with your order for detailed storage requirements. ChemContract Research includes handling and storage documentation with every shipment.
What is the CAS number of 3-fluorocyclobutane-1-carbonitrile?
The CAS Registry Number for 3-fluorocyclobutane-1-carbonitrile is 1552638-51-3. This unique identifier is used worldwide to reference this specific compound in chemical databases, regulatory filings, and scientific literature. ChemContract Research supplies this compound with full quality documentation. Contact us at chemistry@chem-contract.com for availability and pricing.
